FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036778086> ?p ?o ?g. }

• W3036778086 abstract "Non-typhoidal Salmonella (NTS) causes gastrointestinal infection, which is commonly self-limiting in healthy humans but may lead to invasive infection at extraintestinal sites, leading to bacteremia and focal systemic infections in the immunocompromised. However, a prophylactic vaccine against invasive NTS has not yet been developed. In this work, we explored the potential of a ΔyjeK mutant strain as a live attenuated vaccine against invasive NTS infection. YjeK in combination with YjeA is required for the post-translational modification of elongation factor P (EF-P), which is critical for bacterial protein synthesis. Therefore, malfunction of YjeK and YjeA-mediated EF-P activation might extensively influence protein expression during Salmonella infection. Salmonella lacking YjeK showed substantial alterations in bacterial motility, antibiotics resistance, and virulence. Interestingly, deletion of the yjeK gene increased the expression levels of Salmonella pathogenicity island (SPI)-1 genes but decreased the transcription levels of SPI-2 genes, thereby influencing bacterial invasion and survival abilities in contact with host cells. In a mouse model, the ΔyjeK mutant strain alleviated the levels of splenomegaly and bacterial burdens in the spleen and liver in comparison with the wild-type strain. However, mice immunized with the ΔyjeK mutant displayed increased Th1- and Th2-mediated immune responses at 28 days post-infection, promoting cytokines and antibodies production. Notably, the Th2-associated antibody response was highly induced by administration of the ΔyjeK mutant strain. Consequently, vaccination with the ΔyjeK mutant strain protected 100% of the mice against challenge with lethal invasive Salmonella and significantly relieved bacterial burdens in the organs. Collectively, these results suggest that the ΔyjeK mutant strain can be exploited as a promising live attenuated NTS vaccine." @default.
• W3036778086 created "2020-06-25" @default.
• W3036778086 creator A5014930185 @default.
• W3036778086 creator A5030621902 @default.
• W3036778086 creator A5042447580 @default.
• W3036778086 creator A5049559685 @default.
• W3036778086 creator A5050544454 @default.
• W3036778086 creator A5078871289 @default.
• W3036778086 date "2020-06-23" @default.
• W3036778086 modified "2023-10-12" @default.
• W3036778086 title "Salmonella Typhimurium Lacking YjeK as a Candidate Live Attenuated Vaccine Against Invasive Salmonella Infection" @default.
• W3036778086 cites W1576601359 @default.
• W3036778086 cites W1972922050 @default.
• W3036778086 cites W1975913397 @default.
• W3036778086 cites W1978632336 @default.
• W3036778086 cites W1979960455 @default.
• W3036778086 cites W1985782125 @default.
• W3036778086 cites W2002542371 @default.
• W3036778086 cites W2010693453 @default.
• W3036778086 cites W2011164975 @default.
• W3036778086 cites W2025659013 @default.
• W3036778086 cites W2031899577 @default.
• W3036778086 cites W2031943960 @default.
• W3036778086 cites W2040738213 @default.
• W3036778086 cites W2041415001 @default.
• W3036778086 cites W2044493726 @default.
• W3036778086 cites W2053631737 @default.
• W3036778086 cites W2061456837 @default.
• W3036778086 cites W2064187335 @default.
• W3036778086 cites W2073023385 @default.
• W3036778086 cites W2075580750 @default.
• W3036778086 cites W2076934723 @default.
• W3036778086 cites W2089771325 @default.
• W3036778086 cites W2090390408 @default.
• W3036778086 cites W2095721618 @default.
• W3036778086 cites W2100034360 @default.
• W3036778086 cites W2102235987 @default.
• W3036778086 cites W2106814386 @default.
• W3036778086 cites W2111677449 @default.
• W3036778086 cites W2116137883 @default.
• W3036778086 cites W2127386189 @default.
• W3036778086 cites W2134462524 @default.
• W3036778086 cites W2171353303 @default.
• W3036778086 cites W2171396065 @default.
• W3036778086 cites W2185660953 @default.
• W3036778086 cites W2217541405 @default.
• W3036778086 cites W2256756668 @default.
• W3036778086 cites W2319605428 @default.
• W3036778086 cites W2336489338 @default.
• W3036778086 cites W2510015594 @default.
• W3036778086 cites W2567899704 @default.
• W3036778086 cites W2734378828 @default.
• W3036778086 cites W2769744517 @default.
• W3036778086 cites W2771111712 @default.
• W3036778086 cites W2803720100 @default.
• W3036778086 cites W2888620135 @default.
• W3036778086 cites W2904499888 @default.
• W3036778086 cites W2939035775 @default.
• W3036778086 cites W942177091 @default.
• W3036778086 doi "https://doi.org/10.3389/fimmu.2020.01277" @default.
• W3036778086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7324483" @default.
• W3036778086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32655567" @default.
• W3036778086 hasPublicationYear "2020" @default.
• W3036778086 type Work @default.
• W3036778086 sameAs 3036778086 @default.
• W3036778086 citedByCount "7" @default.
• W3036778086 countsByYear W30367780862021 @default.
• W3036778086 countsByYear W30367780862022 @default.
• W3036778086 countsByYear W30367780862023 @default.
• W3036778086 crossrefType "journal-article" @default.
• W3036778086 hasAuthorship W3036778086A5014930185 @default.
• W3036778086 hasAuthorship W3036778086A5030621902 @default.
• W3036778086 hasAuthorship W3036778086A5042447580 @default.
• W3036778086 hasAuthorship W3036778086A5049559685 @default.
• W3036778086 hasAuthorship W3036778086A5050544454 @default.
• W3036778086 hasAuthorship W3036778086A5078871289 @default.
• W3036778086 hasBestOaLocation W30367780861 @default.
• W3036778086 hasConcept C104317684 @default.
• W3036778086 hasConcept C159047783 @default.
• W3036778086 hasConcept C2778782520 @default.
• W3036778086 hasConcept C2781065037 @default.
• W3036778086 hasConcept C523546767 @default.
• W3036778086 hasConcept C54355233 @default.
• W3036778086 hasConcept C54602769 @default.
• W3036778086 hasConcept C60987743 @default.
• W3036778086 hasConcept C86803240 @default.
• W3036778086 hasConcept C89423630 @default.
• W3036778086 hasConceptScore W3036778086C104317684 @default.
• W3036778086 hasConceptScore W3036778086C159047783 @default.
• W3036778086 hasConceptScore W3036778086C2778782520 @default.
• W3036778086 hasConceptScore W3036778086C2781065037 @default.
• W3036778086 hasConceptScore W3036778086C523546767 @default.
• W3036778086 hasConceptScore W3036778086C54355233 @default.
• W3036778086 hasConceptScore W3036778086C54602769 @default.
• W3036778086 hasConceptScore W3036778086C60987743 @default.
• W3036778086 hasConceptScore W3036778086C86803240 @default.
• W3036778086 hasConceptScore W3036778086C89423630 @default.
• W3036778086 hasFunder F4320322120 @default.
• W3036778086 hasLocation W30367780861 @default.
• W3036778086 hasLocation W30367780862 @default.

• next