FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036779907> ?p ?o ?g. }

• W3036779907 endingPage "104974" @default.
• W3036779907 startingPage "104974" @default.
• W3036779907 abstract "Only a minority of trauma-exposed individuals develops Posttraumatic stress disorder (PTSD) and active processes may support trauma resilience. Individual behavioral profiling allows investigating neurobiological alterations related to resilience or pathology in animal models of PTSD and is utilized here to examine the activation of different interneuron subpopulations of the dentate gyrus-amygdala system associated with trauma resilience or pathology. To model PTSD, rats were exposed to juvenile stress combined with underwater trauma (UWT) in adulthood. Four weeks later, individual anxiety levels were assessed in the elevated plus maze test for classifying rats as highly anxious ‘affected’ vs. ‘non-affected’, i.e. behaving as control animals. Analyzing the activation of specific interneuron subpopulations in the dorsal and ventral dentate gyrus (DG), the basolateral (BLA) and central amygdala by immunohistochemical double-labeling for cFos and different interneuron markers, revealed an increased activation of cholecystokinin (CCK)-positive interneurons in the ventral DG, together with increased activation of parvalbumin- and CCK-positive interneurons in the BLA of affected trauma-exposed rats. By contrast, increased activation of neuropeptide Y (NPY)-positive interneurons was observed in the dorsal DG of trauma-exposed, but non-affected rats. To test for a direct contribution of NPY in the dorsal DG to trauma resilience, a local shRNA-mediated knock down was performed after UWT. Such a treatment significantly reduced the prevalence of resilient animals. Our results suggest that distinct interneuron populations are associated with resilience or pathology in PTSD with high regional specificity. NPY within the dorsal DG was found to significantly contribute to trauma resilience." @default.
• W3036779907 created "2020-06-25" @default.
• W3036779907 creator A5014181855 @default.
• W3036779907 creator A5018709602 @default.
• W3036779907 creator A5019562081 @default.
• W3036779907 creator A5044787593 @default.
• W3036779907 creator A5053838945 @default.
• W3036779907 creator A5067258427 @default.
• W3036779907 date "2020-09-01" @default.
• W3036779907 modified "2023-09-26" @default.
• W3036779907 title "Region-specific involvement of interneuron subpopulations in trauma-related pathology and resilience" @default.
• W3036779907 cites W1536586062 @default.
• W3036779907 cites W1551016696 @default.
• W3036779907 cites W1592248289 @default.
• W3036779907 cites W1966869284 @default.
• W3036779907 cites W1969677319 @default.
• W3036779907 cites W1970822380 @default.
• W3036779907 cites W1983092748 @default.
• W3036779907 cites W1988954465 @default.
• W3036779907 cites W1991924547 @default.
• W3036779907 cites W1995644017 @default.
• W3036779907 cites W1999352359 @default.
• W3036779907 cites W2013309206 @default.
• W3036779907 cites W2018696438 @default.
• W3036779907 cites W2025270113 @default.
• W3036779907 cites W2026342268 @default.
• W3036779907 cites W2027966516 @default.
• W3036779907 cites W2034276306 @default.
• W3036779907 cites W2044141517 @default.
• W3036779907 cites W2048625352 @default.
• W3036779907 cites W2051005796 @default.
• W3036779907 cites W2057017838 @default.
• W3036779907 cites W2057743484 @default.
• W3036779907 cites W2058224978 @default.
• W3036779907 cites W2064756281 @default.
• W3036779907 cites W2065418921 @default.
• W3036779907 cites W2067182175 @default.
• W3036779907 cites W2067931177 @default.
• W3036779907 cites W2069203682 @default.
• W3036779907 cites W2074707688 @default.
• W3036779907 cites W2085752437 @default.
• W3036779907 cites W2093139568 @default.
• W3036779907 cites W2103322364 @default.
• W3036779907 cites W2103361829 @default.
• W3036779907 cites W2118826874 @default.
• W3036779907 cites W2137703000 @default.
• W3036779907 cites W2148977391 @default.
• W3036779907 cites W2151994468 @default.
• W3036779907 cites W2157911297 @default.
• W3036779907 cites W2170135464 @default.
• W3036779907 cites W2200927638 @default.
• W3036779907 cites W2202096406 @default.
• W3036779907 cites W2261030667 @default.
• W3036779907 cites W2289891471 @default.
• W3036779907 cites W2289959047 @default.
• W3036779907 cites W2464300497 @default.
• W3036779907 cites W2578165946 @default.
• W3036779907 cites W2739931839 @default.
• W3036779907 cites W2741101766 @default.
• W3036779907 cites W2791838956 @default.
• W3036779907 doi "https://doi.org/10.1016/j.nbd.2020.104974" @default.
• W3036779907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32561495" @default.
• W3036779907 hasPublicationYear "2020" @default.
• W3036779907 type Work @default.
• W3036779907 sameAs 3036779907 @default.
• W3036779907 citedByCount "15" @default.
• W3036779907 countsByYear W30367799072020 @default.
• W3036779907 countsByYear W30367799072021 @default.
• W3036779907 countsByYear W30367799072022 @default.
• W3036779907 countsByYear W30367799072023 @default.
• W3036779907 crossrefType "journal-article" @default.
• W3036779907 hasAuthorship W3036779907A5014181855 @default.
• W3036779907 hasAuthorship W3036779907A5018709602 @default.
• W3036779907 hasAuthorship W3036779907A5019562081 @default.
• W3036779907 hasAuthorship W3036779907A5044787593 @default.
• W3036779907 hasAuthorship W3036779907A5053838945 @default.
• W3036779907 hasAuthorship W3036779907A5067258427 @default.
• W3036779907 hasBestOaLocation W30367799071 @default.
• W3036779907 hasConcept C118303440 @default.
• W3036779907 hasConcept C126322002 @default.
• W3036779907 hasConcept C141547260 @default.
• W3036779907 hasConcept C15744967 @default.
• W3036779907 hasConcept C169760540 @default.
• W3036779907 hasConcept C170493617 @default.
• W3036779907 hasConcept C17077164 @default.
• W3036779907 hasConcept C2776464000 @default.
• W3036779907 hasConcept C2779144063 @default.
• W3036779907 hasConcept C2779296341 @default.
• W3036779907 hasConcept C2780451725 @default.
• W3036779907 hasConcept C2781161787 @default.
• W3036779907 hasConcept C71924100 @default.
• W3036779907 hasConcept C93984277 @default.
• W3036779907 hasConceptScore W3036779907C118303440 @default.
• W3036779907 hasConceptScore W3036779907C126322002 @default.
• W3036779907 hasConceptScore W3036779907C141547260 @default.
• W3036779907 hasConceptScore W3036779907C15744967 @default.
• W3036779907 hasConceptScore W3036779907C169760540 @default.
• W3036779907 hasConceptScore W3036779907C170493617 @default.

• next