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• W3036792692 abstract "Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is considered the cornerstone of laboratory evaluation of male infertility, but it has its own drawbacks and fails to predict the male fertility potential with high sensitivity and specificity. Different etiologies have been linked with male infertility, of which sperm DNA damage has gained significant attention with extensive research on sperm function tests. The associations between sperm DNA damage and a variety of disorders such as varicocele, obesity, cancer, radiation and lifestyle factors are explored in this review. Furthermore, we discuss the mechanisms of DNA damage as well as its impact in different scenarios of male infertility, associated with spontaneous and assisted reproduction. Finally, we review the clinical applicability of sperm DNA fragmentation testing in the management of male infertility." @default.
• W3036792692 created "2020-06-25" @default.
• W3036792692 creator A5016528673 @default.
• W3036792692 creator A5025063876 @default.
• W3036792692 creator A5057033632 @default.
• W3036792692 creator A5079922220 @default.
• W3036792692 date "2020-06-19" @default.
• W3036792692 modified "2023-10-05" @default.
• W3036792692 title "Etiologies of sperm DNA damage and its impact on male infertility" @default.
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