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- W3036804912 abstract "• Yeast develops spatially-organized organelles for specialized metabolic functions. • Design principles of engineering yeast transcriptional factor-based sensors uncovered. • GPCR-based sensor provides a versatile and modular toolset to rewire cell signaling . • Optogenetic sensor directs protein assembly and removes rate-limiting steps. Yeast has been a robust platform to manufacture a broad range of biofuels, commodity chemicals, natural products and pharmaceuticals. The membrane-bound organelles in yeast provide us the means to access the specialized metabolism for various biosynthetic applications. The separation and compartmentalization of genetic and metabolic events presents us the opportunity to precisely control and program gene expression for higher order biological functions. To further advance yeast synthetic biology platform, genetically encoded biosensors and actuators haven been engineered for in vivo monitoring and controlling cellular processes with spatiotemporal resolutions. The dynamic response, sensitivity and operational range of these genetically encoded sensors are determined by the regulatory architecture, dynamic assemly and interactions of the related proteins and genetic elements. This review provides an update of the basic design principles underlying the allosteric transcription factors, GPCR and optogenetics-based sensors, aiming to precisely analyze and control yeast cellular processes for various biotechnological applications." @default.
- W3036804912 created "2020-06-25" @default.
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- W3036804912 date "2020-08-01" @default.
- W3036804912 modified "2023-10-12" @default.
- W3036804912 title "Genetically-encoded biosensors for analyzing and controlling cellular process in yeast" @default.
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- W3036804912 doi "https://doi.org/10.1016/j.copbio.2020.04.006" @default.
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