Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036807127> ?p ?o ?g. }
- W3036807127 endingPage "59" @default.
- W3036807127 startingPage "44" @default.
- W3036807127 abstract "Ischemia-reperfusion injury (IRI) is an important risk factor for accelerated cardiac allograft rejection and graft dysfunction . Utilizing a rat heart isogeneic transplant model, we identified inflammatory pathways involved in IRI in order to identify therapeutic targets involved in disease. Pathway analyses identified several relevant targets, including cytokine signaling by the IL-1 receptor (IL-1R) pathway and inflammasome activation. To investigate the role of IL-1R signaling pathways during IRI, we treated syngeneic cardiac transplant recipients at 1-hour posttransplant with Anakinra, a US Food and Drug Administration (FDA)-approved IL-1R antagonist; or parthenolide, a caspase-1 and nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor that blocks IL-1β maturation. Both Anakinra and parthenolide significantly reduced graft inflammation and cellular recruitment in the treated recipients relative to nontreated controls. Anakinra treatment administered at 1-hour posttransplant to recipients of cardiac allografts from CMV-infected donors significantly increased the time to rejection and reduced viral loads at rejection. Our results indicate that reducing IRI by blocking IL-1Rsignaling pathways with Anakinra or inflammasome activity with parthenolide provides a promising approach for extending survival of cardiac allografts from CMV-infected donors." @default.
- W3036807127 created "2020-06-25" @default.
- W3036807127 creator A5000815038 @default.
- W3036807127 creator A5009204503 @default.
- W3036807127 creator A5012696027 @default.
- W3036807127 creator A5017698587 @default.
- W3036807127 creator A5018885317 @default.
- W3036807127 creator A5034535868 @default.
- W3036807127 creator A5036384666 @default.
- W3036807127 creator A5047580780 @default.
- W3036807127 creator A5052186963 @default.
- W3036807127 creator A5058309915 @default.
- W3036807127 creator A5060908301 @default.
- W3036807127 creator A5062983766 @default.
- W3036807127 creator A5074229907 @default.
- W3036807127 creator A5091870901 @default.
- W3036807127 date "2021-01-01" @default.
- W3036807127 modified "2023-10-18" @default.
- W3036807127 title "Blocking the IL-1 receptor reduces cardiac transplant ischemia and reperfusion injury and mitigates CMV-accelerated chronic rejection" @default.
- W3036807127 cites W1488965868 @default.
- W3036807127 cites W1496323777 @default.
- W3036807127 cites W1502754931 @default.
- W3036807127 cites W1946807613 @default.
- W3036807127 cites W1977032720 @default.
- W3036807127 cites W1978029768 @default.
- W3036807127 cites W1980594957 @default.
- W3036807127 cites W1988523451 @default.
- W3036807127 cites W2008828623 @default.
- W3036807127 cites W2022493256 @default.
- W3036807127 cites W2027132059 @default.
- W3036807127 cites W2044322266 @default.
- W3036807127 cites W2045067290 @default.
- W3036807127 cites W2048048075 @default.
- W3036807127 cites W2049497606 @default.
- W3036807127 cites W2056246066 @default.
- W3036807127 cites W2056668196 @default.
- W3036807127 cites W2060166147 @default.
- W3036807127 cites W2061946173 @default.
- W3036807127 cites W2074130375 @default.
- W3036807127 cites W2107018762 @default.
- W3036807127 cites W2108373994 @default.
- W3036807127 cites W2114635506 @default.
- W3036807127 cites W2131271579 @default.
- W3036807127 cites W2137404162 @default.
- W3036807127 cites W2140842031 @default.
- W3036807127 cites W2146193551 @default.
- W3036807127 cites W2146512944 @default.
- W3036807127 cites W2152079015 @default.
- W3036807127 cites W2155421808 @default.
- W3036807127 cites W2160443244 @default.
- W3036807127 cites W2163007294 @default.
- W3036807127 cites W2169456326 @default.
- W3036807127 cites W2335668304 @default.
- W3036807127 cites W2343539326 @default.
- W3036807127 cites W2432815617 @default.
- W3036807127 cites W2619063001 @default.
- W3036807127 cites W2933128115 @default.
- W3036807127 cites W4255351505 @default.
- W3036807127 doi "https://doi.org/10.1111/ajt.16149" @default.
- W3036807127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33405337" @default.
- W3036807127 hasPublicationYear "2021" @default.
- W3036807127 type Work @default.
- W3036807127 sameAs 3036807127 @default.
- W3036807127 citedByCount "7" @default.
- W3036807127 countsByYear W30368071272022 @default.
- W3036807127 countsByYear W30368071272023 @default.
- W3036807127 crossrefType "journal-article" @default.
- W3036807127 hasAuthorship W3036807127A5000815038 @default.
- W3036807127 hasAuthorship W3036807127A5009204503 @default.
- W3036807127 hasAuthorship W3036807127A5012696027 @default.
- W3036807127 hasAuthorship W3036807127A5017698587 @default.
- W3036807127 hasAuthorship W3036807127A5018885317 @default.
- W3036807127 hasAuthorship W3036807127A5034535868 @default.
- W3036807127 hasAuthorship W3036807127A5036384666 @default.
- W3036807127 hasAuthorship W3036807127A5047580780 @default.
- W3036807127 hasAuthorship W3036807127A5052186963 @default.
- W3036807127 hasAuthorship W3036807127A5058309915 @default.
- W3036807127 hasAuthorship W3036807127A5060908301 @default.
- W3036807127 hasAuthorship W3036807127A5062983766 @default.
- W3036807127 hasAuthorship W3036807127A5074229907 @default.
- W3036807127 hasAuthorship W3036807127A5091870901 @default.
- W3036807127 hasBestOaLocation W30368071271 @default.
- W3036807127 hasConcept C126322002 @default.
- W3036807127 hasConcept C170493617 @default.
- W3036807127 hasConcept C203014093 @default.
- W3036807127 hasConcept C2776885963 @default.
- W3036807127 hasConcept C2776914184 @default.
- W3036807127 hasConcept C2777209026 @default.
- W3036807127 hasConcept C2778122271 @default.
- W3036807127 hasConcept C2779134260 @default.
- W3036807127 hasConcept C2780114680 @default.
- W3036807127 hasConcept C2781228260 @default.
- W3036807127 hasConcept C541997718 @default.
- W3036807127 hasConcept C71924100 @default.
- W3036807127 hasConcept C98274493 @default.
- W3036807127 hasConceptScore W3036807127C126322002 @default.
- W3036807127 hasConceptScore W3036807127C170493617 @default.
- W3036807127 hasConceptScore W3036807127C203014093 @default.