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- W3036817493 abstract "Psoriasis (PSO) is a chronic, inflammatory disease characterized by immune-driven keratinocyte hyperproliferation. We report identification of pro- and anti-inflammatory intestinal microbiota clusters, bacterial and fungal, in psoriatic patients versus healthy controls. We also examined the association between disease severity and the microbiome of psoriasis skin. Fecal and skin samples were obtained from 67 psoriatic patients and 12 healthy controls. Disease severity was assessed by body surface area. 16S (bacterial) and ITS1 region (fungal) genes were amplified and then sequenced using an Ion Torrent S5 system. Relative abundance was determined using non-parametric comparisons. Interestingly, fecal samples showed a pattern of intestinal dysbiosis similar to that previously reported for Crohn’s disease (CD) patients. Clusters of psoriasis endotypes were identified by intestinal dysbiosis favoring pro-inflammatory bacterial and fungal pathobionts. There was a significant increase in Staphylococcus, Serratia, and Enterobacter (p = 0.0267, 0.00092, 0.0076, respectively) as well as fungi including C. albicans and C. Parapslosis (p=0.0286 and 0.0368, respectively) in the gut of psoriatic patients compared to healthy controls. Conversely, microbes known for their beneficial anti-inflammatory properties such as F. prausnitzii and Clostridium were markedly reduced. Similar clustering was observed at the skin level, where we report for the first time a positive correlation between disease severity and increased relative abundance of the pro-inflammatory microbes – S. marcescens, E. coli, and C. albicans. Increased abundance of these three organisms has also been described in the gut of CD patients suggesting a potential link between the microbiota of CD and PSO" @default.
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- W3036817493 date "2020-07-01" @default.
- W3036817493 modified "2023-09-27" @default.
- W3036817493 title "362 Psoriatic fungal and bacterial microbiomes identify patient endotypes" @default.
- W3036817493 doi "https://doi.org/10.1016/j.jid.2020.03.369" @default.
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