Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036830049> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3036830049 endingPage "92" @default.
- W3036830049 startingPage "92" @default.
- W3036830049 abstract "The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models. We conducted a retrospective chart review to explore the analgesic potency of the P2Y12 receptor-specific antagonist, clopidogrel, for clinical management of postoperative pain in patients who underwent abdominal surgery. Twenty-seven patients with cardiovascular comorbidities, who underwent laparoscopic abdominal surgery and had ceased aspirin (ASP, n = 17) or clopidogrel (CLP, n = 10) for 14 days pre-operatively, were enrolled retrospectively. In both groups, the number of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) consumed for managing postoperative pain was compared using the chi-square test and Mann–Whitney test. Our results showed that from postoperative day (POD) 0 to POD 3, the average numerical rating reflecting the postoperative pain was comparable between the two groups (CLP: 4.0 ± 1.4 vs. ASP: 3.7 ± 0.8, P-value = 0.56). However, at POD 7, opioid consumption in the CLP-treated group (fentanyl-equivalent dose: 0.49 ± 0.56 mg) was significantly lower than that in the ASP-treated group (1.48 ± 1.35 mg, P-value = 0.037). After reaching a stable state by repeated systemic administration, clopidogrel sustained the analgesic efficacy for a certain period. In conclusion, microglial P2Y12 receptors may mediate signal transduction of postoperative nociceptive pain and enhance clinical opioid analgesia." @default.
- W3036830049 created "2020-06-25" @default.
- W3036830049 creator A5004784208 @default.
- W3036830049 creator A5005474653 @default.
- W3036830049 creator A5005955691 @default.
- W3036830049 creator A5013210055 @default.
- W3036830049 creator A5015748723 @default.
- W3036830049 creator A5036706162 @default.
- W3036830049 creator A5055534155 @default.
- W3036830049 creator A5076705668 @default.
- W3036830049 creator A5080177316 @default.
- W3036830049 date "2020-06-22" @default.
- W3036830049 modified "2023-09-24" @default.
- W3036830049 title "Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review" @default.
- W3036830049 cites W1578281160 @default.
- W3036830049 cites W1972222177 @default.
- W3036830049 cites W1983877031 @default.
- W3036830049 cites W2006261709 @default.
- W3036830049 cites W2008765449 @default.
- W3036830049 cites W2050181320 @default.
- W3036830049 cites W2080822069 @default.
- W3036830049 cites W2090214585 @default.
- W3036830049 cites W2114003068 @default.
- W3036830049 cites W2131686384 @default.
- W3036830049 cites W2149628072 @default.
- W3036830049 cites W2266654199 @default.
- W3036830049 cites W2606527202 @default.
- W3036830049 cites W2611903851 @default.
- W3036830049 cites W2786438865 @default.
- W3036830049 cites W2914051519 @default.
- W3036830049 cites W2921207173 @default.
- W3036830049 doi "https://doi.org/10.3390/life10060092" @default.
- W3036830049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7344612" @default.
- W3036830049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32580286" @default.
- W3036830049 hasPublicationYear "2020" @default.
- W3036830049 type Work @default.
- W3036830049 sameAs 3036830049 @default.
- W3036830049 citedByCount "3" @default.
- W3036830049 countsByYear W30368300492023 @default.
- W3036830049 crossrefType "journal-article" @default.
- W3036830049 hasAuthorship W3036830049A5004784208 @default.
- W3036830049 hasAuthorship W3036830049A5005474653 @default.
- W3036830049 hasAuthorship W3036830049A5005955691 @default.
- W3036830049 hasAuthorship W3036830049A5013210055 @default.
- W3036830049 hasAuthorship W3036830049A5015748723 @default.
- W3036830049 hasAuthorship W3036830049A5036706162 @default.
- W3036830049 hasAuthorship W3036830049A5055534155 @default.
- W3036830049 hasAuthorship W3036830049A5076705668 @default.
- W3036830049 hasAuthorship W3036830049A5080177316 @default.
- W3036830049 hasBestOaLocation W30368300491 @default.
- W3036830049 hasConcept C126322002 @default.
- W3036830049 hasConcept C170493617 @default.
- W3036830049 hasConcept C2776885963 @default.
- W3036830049 hasConcept C2777107010 @default.
- W3036830049 hasConcept C2777628954 @default.
- W3036830049 hasConcept C2777849778 @default.
- W3036830049 hasConcept C2780120127 @default.
- W3036830049 hasConcept C2780820201 @default.
- W3036830049 hasConcept C42219234 @default.
- W3036830049 hasConcept C49059817 @default.
- W3036830049 hasConcept C71924100 @default.
- W3036830049 hasConcept C98274493 @default.
- W3036830049 hasConceptScore W3036830049C126322002 @default.
- W3036830049 hasConceptScore W3036830049C170493617 @default.
- W3036830049 hasConceptScore W3036830049C2776885963 @default.
- W3036830049 hasConceptScore W3036830049C2777107010 @default.
- W3036830049 hasConceptScore W3036830049C2777628954 @default.
- W3036830049 hasConceptScore W3036830049C2777849778 @default.
- W3036830049 hasConceptScore W3036830049C2780120127 @default.
- W3036830049 hasConceptScore W3036830049C2780820201 @default.
- W3036830049 hasConceptScore W3036830049C42219234 @default.
- W3036830049 hasConceptScore W3036830049C49059817 @default.
- W3036830049 hasConceptScore W3036830049C71924100 @default.
- W3036830049 hasConceptScore W3036830049C98274493 @default.
- W3036830049 hasFunder F4320320212 @default.
- W3036830049 hasIssue "6" @default.
- W3036830049 hasLocation W30368300491 @default.
- W3036830049 hasLocation W30368300492 @default.
- W3036830049 hasLocation W30368300493 @default.
- W3036830049 hasLocation W30368300494 @default.
- W3036830049 hasLocation W30368300495 @default.
- W3036830049 hasOpenAccess W3036830049 @default.
- W3036830049 hasPrimaryLocation W30368300491 @default.
- W3036830049 hasRelatedWork W2010454652 @default.
- W3036830049 hasRelatedWork W2013641304 @default.
- W3036830049 hasRelatedWork W2015641383 @default.
- W3036830049 hasRelatedWork W2105982621 @default.
- W3036830049 hasRelatedWork W2189601282 @default.
- W3036830049 hasRelatedWork W2389793852 @default.
- W3036830049 hasRelatedWork W2574602345 @default.
- W3036830049 hasRelatedWork W2766249749 @default.
- W3036830049 hasRelatedWork W2893815838 @default.
- W3036830049 hasRelatedWork W3010299572 @default.
- W3036830049 hasVolume "10" @default.
- W3036830049 isParatext "false" @default.
- W3036830049 isRetracted "false" @default.
- W3036830049 magId "3036830049" @default.
- W3036830049 workType "article" @default.