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• W3036877093 abstract "Abstract Identifying the directions of signal flows in neural networks is one of the most important stages for understanding the intricate information dynamics of a living brain. Using a dataset of 213 projection neurons distributed in different regions of a Drosophila brain, we develop a powerful machine learning algorithm: node-based polarity identifier of neurons (NPIN). The proposed model is trained by nodal information only and includes both Soma Features (which contain spatial information from a given node to a soma) and Local Features (which contain morphological information of a given node) . After including the spatial correlations between nodal polarities, our NPIN provided extremely high accuracy (>96.0%) for the classification of neuronal polarity, even for complex neurons with more than two dendrite/axon clusters. Finally, we further apply NPIN to classify the neuronal polarity of the blowfly, which has much less neuronal data available. Our results demonstrate that NPIN is a powerful tool to identify the neuronal polarity of insects and to map out the signal flows in the brain’s neural networks. Availability of data and material The FlyCircuit database ( http://www.flycircuit.tw/ ) is provided by the National Center for High-Performance Computing. Code availability We provide an online version of NPIN to be used or tested by other research groups at the following address: https://npin-for-drosophila.herokuapp.com/" @default.
• W3036877093 created "2020-06-25" @default.
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• W3036877093 date "2020-06-20" @default.
• W3036877093 modified "2023-09-26" @default.
• W3036877093 title "Identification of Neuronal Polarity by Node-Based Machine Learning" @default.
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• W3036877093 doi "https://doi.org/10.1101/2020.06.20.160564" @default.
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