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- W3036877227 abstract "Excitation-calcium release (ECR) is one of the first steps in excitation-contraction coupling in striated muscle. In skeletal muscle, there is some evidence that ECR depends on physical interaction between electrical activity at the plasmalemma (PL) and intracellular calcium stores (junctional sarcoplasmic reticulum; JSR). In cardiac muscle, there is very strong evidence for signal transmission from PL through the release of a diffusible transmitter substance, initially at couplings (= JSR tightly apposed to PL). Avian cardiac muscle has no transverse tubules (TT) but JSR, both as part of peripheral couplings (25%) and as extended JSR (EJSR) unattached to PL (75%). A subset of EJSR, corbular SR (CSR), occurs in small numbers in mammalian hearts and, topographically, fills in wherever TT and, thus, interior couplings (i.e. JSR) are missing. The total volume fraction of avian EJSR (75%) + JSR (25%) is identical to murine JSR (>90%) + CSR (< 10%). JSR-total (JSR, EJSR, CSR) establishes calcium release sites at about equidistant locations throughout the volume of a myocyte. Whereas, in avian hearts a signal for calcium release initiated at a peripheral coupling must be propagated transversely for up to 4 μm (cell radius) by quasi “saltatory” propagation of calcium-induced calcium release (CICR) along the EJSR’s junctional processes (JPs = ryanodine sites) eliciting calcium release for contraction at each contact, in mammalian cardiac and in skeletal muscle calcium release is effected in a one-step process through a propagated action potential kickstarting calcium release at each of a string of peripheral and interior couplings located along TT." @default.
- W3036877227 created "2020-06-25" @default.
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- W3036877227 date "1994-01-01" @default.
- W3036877227 modified "2023-09-27" @default.
- W3036877227 title "Corbular (CSR) and extended junctional SR (EJSR) in skeletal muscle" @default.
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- W3036877227 doi "https://doi.org/10.1017/s0424820100168694" @default.
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