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- W3036883668 abstract "Monocyte derived macrophage foam cells, hallmark to the disease atherosclerosis, can be formed in vitro by cell exposure either toβ VLDL , a naturally occurring lipoprotein, or experimentally modified lipoproteins such as acetylated LDL. Binding kinetics of pigeon β VLDL suggest at least two binding sites on pigeon peritoneal macrophages, and these two kinetically identified sites are consistent with two ultrastructurally distinct uptake mechanisms. One of these sites, the * pigeon β VLDL receptor”, is believed to be a form of the native LDL receptor. This βVLDL/LDL receptor relationship on monocyte derived macrophages is evidenced by 40% overlap in receptor competition between LDL and βVLDL. We have previously reported two ligand induced regions for βVLDL binding sites on pigeon monocyte derived macrophages; these are microvilli and membrane ruffles. Since LDL and βVLDL overlap with respect to receptor recognition, it was of interest to determine if the LDL receptor co-localized with the βVLDL receptors. This question has been addressed through 3-D IVEM of whole mount cells which had b een processed for either ligand-gold or immunogold (receptor) chemistry." @default.
- W3036883668 created "2020-06-25" @default.
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- W3036883668 date "1990-08-12" @default.
- W3036883668 modified "2023-09-25" @default.
- W3036883668 title "LDL receptor and /ßVLDL binding: Co-localization on whole-mount pigeon monocyte derived macrophages" @default.
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- W3036883668 doi "https://doi.org/10.1017/s0424820100159424" @default.
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