FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036895273> ?p ?o ?g. }

• W3036895273 endingPage "3088" @default.
• W3036895273 startingPage "3077" @default.
• W3036895273 abstract "Abstract Parkinson’s disease is characterized by the presence of abnormal, intraneuronal α-synuclein aggregates, which may propagate from cell-to-cell in a prion-like manner. However, it remains uncertain where the initial α-synuclein aggregates originate. We have hypothesized that Parkinson’s disease comprises two subtypes. A brain-first (top-down) type, where α-synuclein pathology initially arises in the brain with secondary spreading to the peripheral autonomic nervous system; and a body-first (bottom-up) type, where the pathology originates in the enteric or peripheral autonomic nervous system and then spreads to the brain. We also hypothesized that isolated REM sleep behaviour disorder (iRBD) is a prodromal phenotype for the body-first type. Using multimodal imaging, we tested the hypothesis by quantifying neuronal dysfunction in structures corresponding to Braak stages I, II and III involvement in three distinct patient groups. We included 37 consecutive de novo patients with Parkinson’s disease into this case-control PET study. Patients with Parkinson’s disease were divided into 24 RBD-negative (PDRBD−) and 13 RBD-positive cases (PDRBD+) and a comparator group of 22 iRBD patients. We used 11C-donepezil PET/CT to assess cholinergic (parasympathetic) innervation, 123I-metaiodobenzylguanidine (MIBG) scintigraphy to measure cardiac sympathetic innervation, neuromelanin-sensitive MRI to measure the integrity of locus coeruleus pigmented neurons, and 18F-dihydroxyphenylalanine (FDOPA) PET to assess putaminal dopamine storage capacity. Colon volume and transit times were assessed with CT scans and radiopaque markers. Imaging data from the three groups were interrogated with ANOVA and Kruskal-Wallis tests corrected for multiple comparisons. The PDRBD− and PDRBD+ groups showed similar marked reductions in putaminal FDOPA-specific uptake, whereas two-thirds of iRBD patients had normal scans (P &lt; 10−13, ANOVA). When compared to the PDRBD− patients, the PDRBD+ and iRBD patients showed reduced mean MIBG heart:mediastinum ratios (P &lt; 10−5, ANOVA) and colon 11C-donepezil standard uptake values (P = 0.008, ANOVA). The PDRBD+ group trended towards a reduced mean MRI locus coeruleus: pons ratio compared to PDRBD− (P = 0.07, t-test). In comparison to the other groups, the PDRBD+ group also had enlarged colon volumes (P &lt; 0.001, ANOVA) and delayed colonic transit times (P = 0.01, Kruskal-Wallis). The combined iRBD and PDRBD+ patient data were compatible with a body-first trajectory, characterized by initial loss of cardiac MIBG signal and 11C-colonic donepezil signal followed by loss of putaminal FDOPA uptake. In contrast, the PDRBD− data were compatible with a brain-first trajectory, characterized by primary loss of putaminal FDOPA uptake followed by a secondary loss of cardiac MIBG signal and 11C-donepezil signal. These findings support the existence of brain-first and body-first subtypes of Parkinson’s disease." @default.
• W3036895273 created "2020-06-25" @default.
• W3036895273 creator A5001790127 @default.
• W3036895273 creator A5001935338 @default.
• W3036895273 creator A5004287164 @default.
• W3036895273 creator A5005853815 @default.
• W3036895273 creator A5006803355 @default.
• W3036895273 creator A5007118594 @default.
• W3036895273 creator A5017855871 @default.
• W3036895273 creator A5021159009 @default.
• W3036895273 creator A5044024497 @default.
• W3036895273 creator A5045336469 @default.
• W3036895273 creator A5051582956 @default.
• W3036895273 creator A5061978980 @default.
• W3036895273 creator A5063189551 @default.
• W3036895273 creator A5067787952 @default.
• W3036895273 creator A5070122548 @default.
• W3036895273 creator A5076958686 @default.
• W3036895273 creator A5078062436 @default.
• W3036895273 creator A5080704448 @default.
• W3036895273 creator A5080852796 @default.
• W3036895273 creator A5084644783 @default.
• W3036895273 creator A5090144276 @default.
• W3036895273 date "2020-08-24" @default.
• W3036895273 modified "2023-10-16" @default.
• W3036895273 title "Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study" @default.
• W3036895273 cites W1564387586 @default.
• W3036895273 cites W1776101795 @default.
• W3036895273 cites W1833314573 @default.
• W3036895273 cites W1854508876 @default.
• W3036895273 cites W1965906256 @default.
• W3036895273 cites W1967659552 @default.
• W3036895273 cites W1969541118 @default.
• W3036895273 cites W1988786764 @default.
• W3036895273 cites W1994626123 @default.
• W3036895273 cites W2007528040 @default.
• W3036895273 cites W2014890274 @default.
• W3036895273 cites W2026730083 @default.
• W3036895273 cites W2042336821 @default.
• W3036895273 cites W2044908785 @default.
• W3036895273 cites W2056789752 @default.
• W3036895273 cites W2064284597 @default.
• W3036895273 cites W2073449985 @default.
• W3036895273 cites W2092218365 @default.
• W3036895273 cites W2099693452 @default.
• W3036895273 cites W2102572922 @default.
• W3036895273 cites W2112455323 @default.
• W3036895273 cites W2145850223 @default.
• W3036895273 cites W2159289603 @default.
• W3036895273 cites W2168946626 @default.
• W3036895273 cites W2298757977 @default.
• W3036895273 cites W2309910088 @default.
• W3036895273 cites W2332452266 @default.
• W3036895273 cites W2556130727 @default.
• W3036895273 cites W2577011711 @default.
• W3036895273 cites W2584158948 @default.
• W3036895273 cites W2585744958 @default.
• W3036895273 cites W2607991581 @default.
• W3036895273 cites W2724559439 @default.
• W3036895273 cites W2742762041 @default.
• W3036895273 cites W2781039296 @default.
• W3036895273 cites W2803083570 @default.
• W3036895273 cites W2810263479 @default.
• W3036895273 cites W2889405907 @default.
• W3036895273 cites W2917107887 @default.
• W3036895273 cites W2953534538 @default.
• W3036895273 cites W2955413884 @default.
• W3036895273 cites W2971415209 @default.
• W3036895273 cites W2971640672 @default.
• W3036895273 cites W2995538686 @default.
• W3036895273 doi "https://doi.org/10.1093/brain/awaa238" @default.
• W3036895273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32830221" @default.
• W3036895273 hasPublicationYear "2020" @default.
• W3036895273 type Work @default.
• W3036895273 sameAs 3036895273 @default.
• W3036895273 citedByCount "321" @default.
• W3036895273 countsByYear W30368952732020 @default.
• W3036895273 countsByYear W30368952732021 @default.
• W3036895273 countsByYear W30368952732022 @default.
• W3036895273 countsByYear W30368952732023 @default.
• W3036895273 crossrefType "journal-article" @default.
• W3036895273 hasAuthorship W3036895273A5001790127 @default.
• W3036895273 hasAuthorship W3036895273A5001935338 @default.
• W3036895273 hasAuthorship W3036895273A5004287164 @default.
• W3036895273 hasAuthorship W3036895273A5005853815 @default.
• W3036895273 hasAuthorship W3036895273A5006803355 @default.
• W3036895273 hasAuthorship W3036895273A5007118594 @default.
• W3036895273 hasAuthorship W3036895273A5017855871 @default.
• W3036895273 hasAuthorship W3036895273A5021159009 @default.
• W3036895273 hasAuthorship W3036895273A5044024497 @default.
• W3036895273 hasAuthorship W3036895273A5045336469 @default.
• W3036895273 hasAuthorship W3036895273A5051582956 @default.
• W3036895273 hasAuthorship W3036895273A5061978980 @default.
• W3036895273 hasAuthorship W3036895273A5063189551 @default.
• W3036895273 hasAuthorship W3036895273A5067787952 @default.
• W3036895273 hasAuthorship W3036895273A5070122548 @default.
• W3036895273 hasAuthorship W3036895273A5076958686 @default.
• W3036895273 hasAuthorship W3036895273A5078062436 @default.

• next