FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036898524> ?p ?o ?g. }

• W3036898524 abstract "Abstract Background and Purpose Motor network flexibility, the ability to switch between different neural network connectivity configurations, is a key feature of normal motor behavior and motor learning. Limited flexibility of the motor system to adapt to environmental stimuli is a pervasive feature of mobility impairment in chronic stroke survivors. The reduced capacity to modulate cortical motor network connectivity during motor behavior has been implicated as a key neural mechanism for constrained flexibility of the motor system. However, whether the theory of reduced cortical motor network flexibility prevails in the lower limb corticomotor system and in the context of functional lower limb motor behaviors remains unknown. In this study, we tested the capacity of the lower limb motor cortex to react to external stimuli using transcranial magnetic stimulation (TMS) and the ability of the cortex to modulate motor network connectivity during lower limb motor activity in a group of chronic stroke survivors and age-matched older adult controls. We evaluated the relationship between activity-dependent modulation of TMS-evoked motor cortical connectivity and post-stroke clinical and biomechanical walking function as well as corticospinal excitability of the paretic leg. Methods Chronic stroke survivors (n=14) and older adults (n=9) completed concurrent TMS-electroencephalography (EEG) testing, clinical evaluation, and biomechanical walking assessment. EEG was recorded during TMS delivered over the contralesional (c)M1 and ipsilesional (i)M1 during rest and active ipsilateral plantarflexion. Interhemispheric connectivity was calculated as the post-TMS (0-300ms) imaginary part of coherence value between electrodes overlying cM1 and iM1 within the beta frequency range (15-30Hz). We compared cM1 and iM1 TMS-evoked beta coherence between groups during rest and active conditions and tested associations with walking impairment and paretic leg corticospinal excitability in stroke survivors. Results In older adult controls, TMS-evoked beta coherence was greater compared to stroke survivors and showed a reduction from rest during active motor conditions regardless of hemisphere. Stroke survivors showed lower TMS-evoked beta coherence during cM1 TMS and a lack of modulation between rest and active conditions. Higher cM1 TMS-evoked beta coherence at rest and reduction of beta coherence during paretic plantarflexion was associated with greater paretic ankle moment during walking and lower levels of clinical lower limb motor impairment. Increased beta coherence during iM1 TMS at rest was associated with the presence of a MEP in the paretic lower limb. Conclusions We found that, like findings in animal models and the upper limb, the lower limb corticomotor system showed reduced cortical network reactivity to external stimuli (TMS), and impaired modulation of cortical network connectivity during lower limb motor activity after stroke. Impaired cortical reactivity and modulation were associated with post-stroke clinical and biomechanical walking function and corticomotor excitability of the paretic leg, supporting the link between cortical network connectivity, motor network flexibility and lower limb motor behavior. These findings have important implications for the development of targeted and individualized treatments to improve lower limb disability in stroke survivors." @default.
• W3036898524 created "2020-06-25" @default.
• W3036898524 creator A5015790093 @default.
• W3036898524 creator A5042718339 @default.
• W3036898524 creator A5055799701 @default.
• W3036898524 creator A5075066856 @default.
• W3036898524 date "2020-06-19" @default.
• W3036898524 modified "2023-09-23" @default.
• W3036898524 title "Cortical motor network flexibility during lower limb motor activity and deficiencies after stroke" @default.
• W3036898524 cites W1572653016 @default.
• W3036898524 cites W1967525341 @default.
• W3036898524 cites W1967681807 @default.
• W3036898524 cites W1986735990 @default.
• W3036898524 cites W1993622316 @default.
• W3036898524 cites W1997906034 @default.
• W3036898524 cites W2000125146 @default.
• W3036898524 cites W2002641851 @default.
• W3036898524 cites W2006874412 @default.
• W3036898524 cites W2021742495 @default.
• W3036898524 cites W2024043297 @default.
• W3036898524 cites W2026640911 @default.
• W3036898524 cites W2047846607 @default.
• W3036898524 cites W2048156150 @default.
• W3036898524 cites W2059976173 @default.
• W3036898524 cites W2066208396 @default.
• W3036898524 cites W2066443881 @default.
• W3036898524 cites W2073633782 @default.
• W3036898524 cites W2077491345 @default.
• W3036898524 cites W2085794218 @default.
• W3036898524 cites W2099389810 @default.
• W3036898524 cites W2104721123 @default.
• W3036898524 cites W2108746366 @default.
• W3036898524 cites W2111960226 @default.
• W3036898524 cites W2115868911 @default.
• W3036898524 cites W2116153809 @default.
• W3036898524 cites W2133947591 @default.
• W3036898524 cites W2140358254 @default.
• W3036898524 cites W2142029338 @default.
• W3036898524 cites W2144571169 @default.
• W3036898524 cites W2153156254 @default.
• W3036898524 cites W2172114682 @default.
• W3036898524 cites W2172257310 @default.
• W3036898524 cites W2194913939 @default.
• W3036898524 cites W2288470135 @default.
• W3036898524 cites W2319721905 @default.
• W3036898524 cites W2465343644 @default.
• W3036898524 cites W2531750099 @default.
• W3036898524 cites W2573343474 @default.
• W3036898524 cites W2622731166 @default.
• W3036898524 cites W2624771167 @default.
• W3036898524 cites W2770123655 @default.
• W3036898524 cites W2802137293 @default.
• W3036898524 cites W2805733562 @default.
• W3036898524 cites W2806756712 @default.
• W3036898524 cites W2895544752 @default.
• W3036898524 cites W2898524175 @default.
• W3036898524 cites W2909662764 @default.
• W3036898524 cites W2938863622 @default.
• W3036898524 cites W2949643979 @default.
• W3036898524 cites W2950858886 @default.
• W3036898524 cites W2963248098 @default.
• W3036898524 cites W2965374917 @default.
• W3036898524 cites W2974100836 @default.
• W3036898524 cites W2996633401 @default.
• W3036898524 cites W3016696635 @default.
• W3036898524 cites W656986214 @default.
• W3036898524 doi "https://doi.org/10.1101/2020.06.15.20130773" @default.
• W3036898524 hasPublicationYear "2020" @default.
• W3036898524 type Work @default.
• W3036898524 sameAs 3036898524 @default.
• W3036898524 citedByCount "2" @default.
• W3036898524 countsByYear W30368985242021 @default.
• W3036898524 crossrefType "posted-content" @default.
• W3036898524 hasAuthorship W3036898524A5015790093 @default.
• W3036898524 hasAuthorship W3036898524A5042718339 @default.
• W3036898524 hasAuthorship W3036898524A5055799701 @default.
• W3036898524 hasAuthorship W3036898524A5075066856 @default.
• W3036898524 hasBestOaLocation W30368985241 @default.
• W3036898524 hasConcept C105795698 @default.
• W3036898524 hasConcept C121332964 @default.
• W3036898524 hasConcept C151730666 @default.
• W3036898524 hasConcept C15744967 @default.
• W3036898524 hasConcept C169760540 @default.
• W3036898524 hasConcept C171139928 @default.
• W3036898524 hasConcept C24998067 @default.
• W3036898524 hasConcept C2778373776 @default.
• W3036898524 hasConcept C2778581513 @default.
• W3036898524 hasConcept C2779343474 @default.
• W3036898524 hasConcept C2780307956 @default.
• W3036898524 hasConcept C2780598303 @default.
• W3036898524 hasConcept C2780645631 @default.
• W3036898524 hasConcept C33923547 @default.
• W3036898524 hasConcept C71924100 @default.
• W3036898524 hasConcept C86803240 @default.
• W3036898524 hasConcept C97355855 @default.
• W3036898524 hasConcept C99508421 @default.
• W3036898524 hasConceptScore W3036898524C105795698 @default.
• W3036898524 hasConceptScore W3036898524C121332964 @default.
• W3036898524 hasConceptScore W3036898524C151730666 @default.
• W3036898524 hasConceptScore W3036898524C15744967 @default.

• next