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- W3036929947 abstract "ABSTRACT The physiological role of the amyloid-precursor protein (APP) is insufficiently understood. Recent work has implicated APP in the regulation of synaptic plasticity. Substantial evidence exists for a role of APP and its secreted ectodomain APPsα in Hebbian plasticity. Here, we addressed the relevance of APP in homeostatic synaptic plasticity using organotypic tissue cultures of APP −/− mice. In the absence of APP, dentate granule cells failed to strengthen their excitatory synapses homeostatically. Homeostatic plasticity is rescued by amyloid-β (Aβ) and not by APPsα, and it is neither observed in APP +/+ tissue treated with β- or γ-secretase inhibitors nor in synaptopodin-deficient cultures lacking the Ca 2+ -dependent molecular machinery of the spine apparatus. Together, these results suggest a role of APP processing via the amyloidogenic pathway in homeostatic synaptic plasticity, representing a function of relevance for brain physiology as well as for brain states associated with increased Aβ levels." @default.
- W3036929947 created "2020-06-25" @default.
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- W3036929947 date "2020-06-22" @default.
- W3036929947 modified "2023-09-23" @default.
- W3036929947 title "Amyloid-beta mediates homeostatic synaptic plasticity" @default.
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- W3036929947 doi "https://doi.org/10.1101/2020.06.22.152066" @default.
- W3036929947 hasPublicationYear "2020" @default.
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