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- W3036931872 abstract "Abstract Disturbed activation of autophagy is implicated in the pathogenesis of inflammatory bowel disease. Accordingly, several autophagy-related genes have been identified as Crohn’s disease susceptibility genes. We screened the autophagy activators from a library including 3,922 natural extracts using a high-throughput assay system. The extracts identified as autophagy activators were administered to mice with 2% dextran sodium sulfate (DSS). Among the autophagy inducers, Sanguisorba officinalis L . (SO) suppressed DSS-induced colitis. To identify the mechanism by which SO ameliorates colitis, epithelial cell and innate myeloid cells-specific Atg7 -deficient mice ( Villin-cre; Atg7 f/f and LysM-cre; Atg7 f/f mice, respectively) were analyzed. SO-mediated inhibition of colitis was observed in Villin-cre ; Atg7 f/f mice. However, SO and a mixture of its components including catechin acid, ellagic acid, gallic acid, and ziyuglycoside II (Mix 4 ) did not suppressed colitis in LysM-cre ; Atg7 f/f mice. In large intestinal macrophages (Mφ) of Atg7 f/f mice, SO and Mix 4 upregulated the expression of marker genes of anti-inflammatory Mφ including Arg1 , Cd206 , and Relma . However, these alterations were not induced in LysM-cre ; Atg7 f/f mice. These findings indicate that SO and its active components ameliorate DSS-induced colitis by providing intestinal Mφ with anti-inflammatory profiles via promotion of Atg7-dependent autophagy." @default.
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- W3036931872 date "2020-06-19" @default.
- W3036931872 modified "2023-10-17" @default.
- W3036931872 title "Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages" @default.
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- W3036931872 doi "https://doi.org/10.1038/s41598-020-65306-4" @default.
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- W3036931872 hasPublicationYear "2020" @default.
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