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- W3036945504 abstract "Atopic dermatitis (AD) is one of the most common inflammatory diseases of childhood and has been associated with comorbid mental health outcomes, but there are limited data on the development of depression during childhood and adolescence, which may be a critical period for intervention. To understand origins of the relationship between AD and depression, accounting for heterogeneity in AD disease activity and severity over time, we analyzed data from an existing longitudinal cohort study representative of the UK population including 13,979 children followed from birth into adolescence. AD annual period prevalence and severity were measured using a standardized and validated question about flexural dermatitis; depressive symptoms were measured using the Short Moods and Feelings Questionnaire (SMFQ) at multiple ages. Period prevalence of AD ranged from 12.8%-18.6%, and clinically significant depressive symptoms ranged from 6.0% -17.9%. Using cross-sectional multivariable logistic regression, we tested the hypothesis that active AD in the past year was associated with SMFQ scores at 5 time points between ages 10 and 16. After controlling for potential confounders including sex, ethnicity, asthma/rhinitis, socioeconomic status and maternal mental health, we found that any active AD was associated with a 13-46% increase in the odds of depression, but the association was only significant at age 16 (OR:1.46, 95%CI 1.04-1.90), and that participants with moderate/severe disease consistently had higher odds of depression. Including a history of asthma or allergies as potential mediators did not substantially change the effect sizes. When inflammatory markers linked to depression (IL-6 and CRP) were additionally included in the models, effect sizes did not change, suggesting that other markers or mechanisms are likely to explain the association. Our results highlight the importance of interventions to address depression among children with AD, especially those with more severe disease and active disease during adolescence." @default.
- W3036945504 created "2020-06-25" @default.
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- W3036945504 date "2020-07-01" @default.
- W3036945504 modified "2023-10-18" @default.
- W3036945504 title "482 Longitudinal cohort study of the association between atopic dermatitis and depression throughout childhood" @default.
- W3036945504 doi "https://doi.org/10.1016/j.jid.2020.03.490" @default.
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