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• W3036950360 abstract "Background: The clinical and prognostic value of programmed death-ligand 1, PD-L1, in glioblastoma remains controversial. The present study aimed to identify the expression of PD-L1 for its prognostic value in glioblastoma. Methods: A comprehensive literature search was performed using the PubMed and CNKI databases. The overall survival (OS) and disease-free survival (DFS) of GBM was analyzed based on Hazard ratios (HRs) and 95% confidence intervals (CIs). Furthermore, Odds ratios (ORs) and 95% CIs were summarized for clinicopathological parameters. The statistical analysis was using RevMan 5.3 software. Results: The meta-analysis was performed by using total nine studies including 806 patients who had glioblastoma. The pooled results indicated that PD-L1 expression in tumor tissues was significantly related to a poor OS (HR = 1.63, 95%CI: 1.19-2.24, P = 0.003, random effects model) with heterogeneity (I2 = 51%). In subgroup analyses, PD-L1 positivity was significantly associated with a worse OS for patients of American and Asian regions, but not for those of European regions. Moreover, PD-L1 expression implied a trend toward the mutation status of the IDH1 gene [coding the Isocitrate Dehydrogenase (NADP(+))-1 protein] (HR = 9.92, 95%CI: 1.85-53.08, P = 0.007, fixed effects model). However, the prediction overall survival (OS) of the patients showed that PD-L1 expression was independent from other clinicopathological features, such as gender and age. Conclusions: Our analyses indicated that high expression of PD-L1 in glioblastoma tumor tissues is associated with poor survival of patients, and PD-L1 may act as a prognostic predictor and an effective therapeutic target for glioblastoma." @default.
• W3036950360 created "2020-06-25" @default.
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• W3036950360 date "2020-06-24" @default.
• W3036950360 modified "2023-10-14" @default.
• W3036950360 title "PD-L1 Expression in Glioblastoma, the Clinical and Prognostic Significance: A Systematic Literature Review and Meta-Analysis" @default.
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• W3036950360 cites W1913780655 @default.
• W3036950360 cites W1936956202 @default.
• W3036950360 cites W1967908989 @default.
• W3036950360 cites W1969765578 @default.
• W3036950360 cites W1972882573 @default.
• W3036950360 cites W1976269164 @default.
• W3036950360 cites W1978857579 @default.
• W3036950360 cites W1979140041 @default.
• W3036950360 cites W1986354050 @default.
• W3036950360 cites W1998941426 @default.
• W3036950360 cites W2002582030 @default.
• W3036950360 cites W2013090484 @default.
• W3036950360 cites W2044400894 @default.
• W3036950360 cites W2050302729 @default.
• W3036950360 cites W2051083170 @default.
• W3036950360 cites W2052225969 @default.
• W3036950360 cites W2053393698 @default.
• W3036950360 cites W2062956416 @default.
• W3036950360 cites W2070580147 @default.
• W3036950360 cites W2084945856 @default.
• W3036950360 cites W2086509569 @default.
• W3036950360 cites W2088369230 @default.
• W3036950360 cites W2092618575 @default.
• W3036950360 cites W2093463728 @default.
• W3036950360 cites W2097049582 @default.
• W3036950360 cites W2099418348 @default.
• W3036950360 cites W2112936527 @default.
• W3036950360 cites W2116371946 @default.
• W3036950360 cites W2116475791 @default.
• W3036950360 cites W2123918574 @default.
• W3036950360 cites W2130511906 @default.
• W3036950360 cites W2133499518 @default.
• W3036950360 cites W2143772132 @default.
• W3036950360 cites W2148977460 @default.
• W3036950360 cites W2158348986 @default.
• W3036950360 cites W2168463296 @default.
• W3036950360 cites W2196159484 @default.
• W3036950360 cites W2277018179 @default.
• W3036950360 cites W2366536035 @default.
• W3036950360 cites W2405335500 @default.
• W3036950360 cites W2462122693 @default.
• W3036950360 cites W2508350822 @default.
• W3036950360 cites W2527905628 @default.
• W3036950360 cites W2560367415 @default.
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• W3036950360 cites W2607567876 @default.
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• W3036950360 cites W2615603032 @default.
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• W3036950360 cites W2793615081 @default.
• W3036950360 cites W2794763378 @default.
• W3036950360 cites W2799381938 @default.
• W3036950360 cites W2806497641 @default.
• W3036950360 cites W2843068538 @default.
• W3036950360 cites W2885696745 @default.
• W3036950360 cites W2897033359 @default.
• W3036950360 cites W2897222331 @default.
• W3036950360 cites W2898788563 @default.
• W3036950360 cites W2900254393 @default.
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• W3036950360 cites W2911871569 @default.
• W3036950360 cites W2921601294 @default.
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• W3036950360 doi "https://doi.org/10.3389/fonc.2020.01015" @default.
• W3036950360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7326811" @default.
• W3036950360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32670884" @default.
• W3036950360 hasPublicationYear "2020" @default.
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