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- W3036952743 abstract "The most active cells in a primary or metastatic carcinoma appear to interface the normal tissue (e.g., at the edge of the tumor mass or adjacent to other normal tissues). These cells, which are free of normal territory-restricting constraints, are characterized by a different morphology from the main mass of tumor cells by pseudopodia formation with pronounced filamentous actin organization, and (usually) with release of proteases including characteristic collagenases. We have developed two types of tissue culture models which give opportunity for 3-D thick-section HVEM and cytochemical study of the transition from the resting stage to the stage of invasive motility. We mean to define the conditions for this transition and to suggest therapies to control the leakage of invasive cells from the main tumor mass into normal tissues. The work is aimed at demonstrating the morphologic and cytochemical relationships between the invasive cells of human and mouse squamous cell tumors, the stem cells (“dark cells”) of normal and embryonic epithelial cells." @default.
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- W3036952743 date "1981-08-01" @default.
- W3036952743 modified "2023-09-27" @default.
- W3036952743 title "Distinguishing Characteristics of the Sub-Population of Squamous Cancer Cells with Invasive Motility—Light Microscope and HVEM Studies" @default.
- W3036952743 cites W2120266735 @default.
- W3036952743 doi "https://doi.org/10.1017/s0424820100098794" @default.
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