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- W303695735 abstract "In the presence of 100 ..mu..g/ml of carrageenans (CAR), B6D2F/sub 1/ responder spleen cells failed to generate antiparent or anti-allogeneic cytotoxic T lymphocytes in vitro, but instead generated suppressor cells. Cultured CAR-treated cells added to mixtures of B6D2F/sub 1/ anti-B6 or B6D2F/sub 1/ anti-C3H cytotoxic effectors (induced in vitro) and the appropriate /sup 51/Cr-labeled lymphoma targets reduced or abolished cytolysis (measured as /sup 51/Cr release) depending on the ratio of suppressor to effector cells. Cultured spleen cells not exposed to CAR failed to inhibit both types of cytotoxicity. Presuppressor cells were associated with a splenic subpopulation independent of the thymus (i.e., present in spleens of athymic nude mice), were moderately adherent to Sephadex G-10 columns, but were not phagocytic or ''sticky'' to carbonyl iron particles. Activation of such cells by CAR was not prevented by in vitro exposure to 2000 rads of ..gamma..-rays before culture, nor facilitated by antigenic stimulation. The matured suppressor cells remained radioresistant and became strongly adherent to Sephadex G-10. The suppressors lacked surface Thy-1 alloantigen detectable by antibody and rabbit complement. Suppressor cell activity was not restricted by the immunologic specificity and major histocompatibility type of effectors." @default.
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- W303695735 date "1978-11-01" @default.
- W303695735 modified "2023-09-27" @default.
- W303695735 title "Suppression of cytotoxic T lymphocytes by carrageenan-activated macrophage-like cells. [Gamma radiation]" @default.
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