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- W3036960247 abstract "The widespread occurrence and high mortality rate in older men associated with disseminated adenocarcinoma of the prostate provide a strong impetus for basic studies of the normal and neoplastic prostate gland. The present studies have been undertaken with the objective of gaining a fuller appreciation of histo- and cytologic interrelationships between metaplastic prostatic tumors and their host organs. The Dunning rat adenocarcinoma has provided a model for some years for the study of primary prostatic tumors, and recently a tumor subline has been identified which preferentially metastasizes to lung (Dr. David M. Lubaroff, U. IA). Cells of the metastatic subline colonize lung following intravenous injection, and produce widespread lesions within the lung parenchyma, and deep to the visceral pleura, in a matter of weeks. Correlative light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic studies have been conducted of both the primary Dunning tumor, and the metastatic lesions within lung, using routine preparative techniques. Morphological examination has been conducted in concert with immunocytochemical localization of components of the extracellular matrix, within both lung and tumor, and with studies of the growth and attachment characteristics of tumor cells cultured in wells coated with such extracellular matrix components as fibronectin, laminin, and collagen types I and IV." @default.
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- W3036960247 date "1990-08-12" @default.
- W3036960247 modified "2023-09-27" @default.
- W3036960247 title "Cell biological studies of primary and metastatic tumors of the rat prostate" @default.
- W3036960247 cites W1929465924 @default.
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- W3036960247 doi "https://doi.org/10.1017/s0424820100159072" @default.
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