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- W3036978401 endingPage "4469" @default.
- W3036978401 startingPage "4469" @default.
- W3036978401 abstract "The therapeutic approach to Chronic Myeloid Leukemia (CML) has changed since the advent of the tyrosine kinase inhibitor (TKI) imatinib, which was then followed by the second generation TKIs dasatinib, nilotinib, and, finally, by ponatinib, a third-generation drug. At present, these therapeutic options represent the first-line treatment for adults. Based on clinical experience, imatinb, dasatinib, and nilotinib have been approved for children even though the studies that were concerned with efficacy and safety toward pediatric patients are still awaiting more specific and high-quality data. In this scenario, it is of utmost importance to prospectively validate data extrapolated from adult studies to set a standard therapeutic management for pediatric CML by employing appropriate formulations on the basis of pediatric clinical trials, which allow a careful monitoring of TKI-induced adverse effects especially in growing children exposed to long-term therapy." @default.
- W3036978401 created "2020-06-25" @default.
- W3036978401 creator A5009793363 @default.
- W3036978401 creator A5024713963 @default.
- W3036978401 creator A5024737795 @default.
- W3036978401 creator A5048477086 @default.
- W3036978401 creator A5059230325 @default.
- W3036978401 creator A5059967824 @default.
- W3036978401 creator A5075487419 @default.
- W3036978401 creator A5091296814 @default.
- W3036978401 date "2020-06-23" @default.
- W3036978401 modified "2023-09-26" @default.
- W3036978401 title "Bcr-Abl Tyrosine Kinase Inhibitors in the Treatment of Pediatric CML" @default.
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