Matches in SemOpenAlex for { <https://semopenalex.org/work/W3036981554> ?p ?o ?g. }
- W3036981554 endingPage "1514" @default.
- W3036981554 startingPage "1514" @default.
- W3036981554 abstract "Huntington’s disease is a severe and currently incurable neurodegenerative disease. An autosomal dominant mutation in the Huntingtin gene (HTT) causes an increase in the polyglutamine fragment length at the protein N-terminus. The consequence of the mutation is the death of neurons, mostly striatal neurons, leading to the occurrence of a complex of motor, cognitive and emotional-volitional personality sphere disorders in carriers. Despite intensive studies, the functions of both mutant and wild-type huntingtin remain poorly understood. Surprisingly, there is the selective effect of the mutant form of HTT even on nervous tissue, whereas the protein is expressed ubiquitously. Huntingtin plays a role in cell physiology and affects cell transport, endocytosis, protein degradation and other cellular and molecular processes. Our experimental data mining let us conclude that a significant part of the Huntingtin-involved cellular processes is mediated by microtubules and other cytoskeletal cell structures. The review attempts to look at unresolved issues in the study of the huntingtin and its mutant form, including their functions affecting microtubules and other components of the cell cytoskeleton." @default.
- W3036981554 created "2020-06-25" @default.
- W3036981554 creator A5010615571 @default.
- W3036981554 creator A5025518139 @default.
- W3036981554 creator A5039629225 @default.
- W3036981554 creator A5047780760 @default.
- W3036981554 date "2020-06-22" @default.
- W3036981554 modified "2023-09-27" @default.
- W3036981554 title "Huntington’s Disease—An Outlook on the Interplay of the HTT Protein, Microtubules and Actin Cytoskeletal Components" @default.
- W3036981554 cites W1453753632 @default.
- W3036981554 cites W1489116022 @default.
- W3036981554 cites W1489178621 @default.
- W3036981554 cites W1588073494 @default.
- W3036981554 cites W1596467522 @default.
- W3036981554 cites W1666768116 @default.
- W3036981554 cites W1881571321 @default.
- W3036981554 cites W1906905763 @default.
- W3036981554 cites W1940885739 @default.
- W3036981554 cites W1959740341 @default.
- W3036981554 cites W1963552002 @default.
- W3036981554 cites W1965404941 @default.
- W3036981554 cites W1970264904 @default.
- W3036981554 cites W1970639161 @default.
- W3036981554 cites W1971810178 @default.
- W3036981554 cites W1973055895 @default.
- W3036981554 cites W1975217735 @default.
- W3036981554 cites W1975638468 @default.
- W3036981554 cites W1977383752 @default.
- W3036981554 cites W1979431825 @default.
- W3036981554 cites W1981397772 @default.
- W3036981554 cites W1981471255 @default.
- W3036981554 cites W1984394485 @default.
- W3036981554 cites W1985501881 @default.
- W3036981554 cites W1985734261 @default.
- W3036981554 cites W1988976106 @default.
- W3036981554 cites W1990406694 @default.
- W3036981554 cites W1991311491 @default.
- W3036981554 cites W1991909451 @default.
- W3036981554 cites W1994285647 @default.
- W3036981554 cites W1994336523 @default.
- W3036981554 cites W1996381116 @default.
- W3036981554 cites W1997122736 @default.
- W3036981554 cites W2006524711 @default.
- W3036981554 cites W2007157911 @default.
- W3036981554 cites W2007785335 @default.
- W3036981554 cites W2008578910 @default.
- W3036981554 cites W2009233191 @default.
- W3036981554 cites W2011464940 @default.
- W3036981554 cites W2012024892 @default.
- W3036981554 cites W2012136237 @default.
- W3036981554 cites W2012783472 @default.
- W3036981554 cites W2015004261 @default.
- W3036981554 cites W2015005644 @default.
- W3036981554 cites W2018088211 @default.
- W3036981554 cites W2020518096 @default.
- W3036981554 cites W2020857992 @default.
- W3036981554 cites W2025615154 @default.
- W3036981554 cites W2026734788 @default.
- W3036981554 cites W2027458086 @default.
- W3036981554 cites W2028159081 @default.
- W3036981554 cites W2029638099 @default.
- W3036981554 cites W2030341400 @default.
- W3036981554 cites W2030410903 @default.
- W3036981554 cites W2030446659 @default.
- W3036981554 cites W2031280902 @default.
- W3036981554 cites W2032146509 @default.
- W3036981554 cites W2032730097 @default.
- W3036981554 cites W2034229701 @default.
- W3036981554 cites W2039526500 @default.
- W3036981554 cites W2041206504 @default.
- W3036981554 cites W2042567578 @default.
- W3036981554 cites W2042716629 @default.
- W3036981554 cites W2045232671 @default.
- W3036981554 cites W2045291478 @default.
- W3036981554 cites W2048802800 @default.
- W3036981554 cites W2049225918 @default.
- W3036981554 cites W2052935486 @default.
- W3036981554 cites W2057095204 @default.
- W3036981554 cites W2057541896 @default.
- W3036981554 cites W2057810961 @default.
- W3036981554 cites W2057886219 @default.
- W3036981554 cites W2059577521 @default.
- W3036981554 cites W2060757466 @default.
- W3036981554 cites W2061270368 @default.
- W3036981554 cites W2061414672 @default.
- W3036981554 cites W2065139981 @default.
- W3036981554 cites W2066052286 @default.
- W3036981554 cites W2069686570 @default.
- W3036981554 cites W2073510453 @default.
- W3036981554 cites W2075189940 @default.
- W3036981554 cites W2080118783 @default.
- W3036981554 cites W2082501455 @default.
- W3036981554 cites W2083213965 @default.
- W3036981554 cites W2084158780 @default.
- W3036981554 cites W2084636668 @default.
- W3036981554 cites W2085073015 @default.
- W3036981554 cites W2085242832 @default.
- W3036981554 cites W2086431203 @default.