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• W3036982912 endingPage "158760" @default.
• W3036982912 startingPage "158760" @default.
• W3036982912 abstract "Sphingosine-1-phosphate receptor-1 (S1PR1), a G-protein coupled receptor that is expressed in endothelium and activated upon ligation by the bioactive lipid sphingosine-1-phosphate (S1P), is an important vascular-barrier protective mechanism at the level of adherens junctions (AJ). Loss of endothelial barrier function is a central factor in the pathogenesis of various inflammatory conditions characterized by protein-rich lung edema formation, such as acute respiratory distress syndrome (ARDS). While several S1PR1 agonists are available, the challenge of arresting the progression of protein-rich edema formation remains to be met. In this review, we discuss the role of S1PRs, especially S1PR1, in regulating endothelial barrier function. We review recent findings showing that replenishment of the pool of cell-surface S1PR1 may be crucial to the effectiveness of S1P in repairing the endothelial barrier. In this context, we discuss the S1P generating machinery and mechanisms that regulate S1PR1 at the cell surface and their impact on endothelial barrier function." @default.
• W3036982912 created "2020-06-25" @default.
• W3036982912 creator A5087479152 @default.
• W3036982912 creator A5068093921 @default.
• W3036982912 date "2020-09-01" @default.
• W3036982912 modified "2023-10-18" @default.
• W3036982912 title "Post-translational modifications of S1PR1 and endothelial barrier regulation" @default.
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