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- W3037040913 abstract "Abstract Salivary glands are exocrine organs that produce and secrete saliva into the oral cavity. Through the use of rodent models, the cellular and molecular processes leading to the development and functionality of secretory branching organs, such as the salivary glands, have been studied in great detail. Gland ontogenesis, development, and maturation are regulated by a series of signaling mechanisms and cellular interactions between the mesenchyme, nerves, blood vessels, and epithelium. Several recent studies have reported the presence of epithelial stem/progenitor cells, which respond to the surrounding environment to expand themselves and/or differentiate into specific cell types of functional saliva-producing gland. This type of research has significantly expanded our understanding of how organs develop and function. It also enhanced the translational concepts of manipulating signaling pathways and/or various cell types in the gland to aid patients who suffer from debilitating diseases, conditions, or syndromes that lead to loss in saliva production. While rodent models are used to analyze these processes, multiple labs have highlighted the comparison of gene expression, cell surface markers, stem cell markers, and protein expression to the human system. Here we summarize and compare our current knowledge on the embryology and physiology of the mouse and human salivary glands, and how stem/progenitor cell populations may contribute to these processes." @default.
- W3037040913 created "2020-07-02" @default.
- W3037040913 creator A5006811449 @default.
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- W3037040913 date "2021-01-01" @default.
- W3037040913 modified "2023-09-26" @default.
- W3037040913 title "Salivary Gland Embryology, Physiology, and Stem Cell Complexity" @default.
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- W3037040913 doi "https://doi.org/10.1016/b978-0-323-67236-8.00002-x" @default.
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