FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W303704380> ?p ?o ?g. }

• W303704380 endingPage "348" @default.
• W303704380 startingPage "333" @default.
• W303704380 abstract "This chapter briefly addresses the well-characterized restriction-modification system (R-M), non-sugar-specific nucleases (SNSN), and histone-like nucleoid structuring (H-NS). It more specifically elaborates on clustered regularly interspaced short palindromic repeats (CRISPR). CRISPR/CRISPR-associated (Cas), a recently described microbial system, provides acquired immunity against phages and plasmids by targeting nucleic acids in a sequence-specific manner. CRISPR features may be exploited for typing purposes, ecological and epidemiological studies, and also for enhancing phage resistance in bacteria. R-M systems commonly act as the first line of intracellular defense against foreign DNA. Some SNSN, such as Vvn from Vibrio vulnificus and EndoI from Escherichia coli, are periplasmic and thus prevent the uptake of foreign DNA. The ubiquitous and predatory nature of phages may explain the overwhelming representation of phage sequences in CRISPR spacers, but a recent report showed that CRISPR can dramatically impact the ability of plasmids to transfer genetic material in Staphylococcus epidermidis. Also, this study experimentally confirmed that CRISPR targets DNA directly in Staphylococcus. The CRISPR RNAs (crRNAs) seem to specifically guide the Cas defense apparatus toward foreign nucleic acid molecules that match the sequence of the spacers. This study also showed that Cas3, a predicted HD nuclease fused to a DEAD-box helicase, is required for the phage-resistance phenotype. The extent of the impact of CRISPR on phage genomes is perhaps best illustrated by extensive genome recombination events observed in environmental phage populations in response to CRISPR." @default.
• W303704380 created "2016-06-24" @default.
• W303704380 creator A5008191157 @default.
• W303704380 creator A5085166852 @default.
• W303704380 date "2014-04-09" @default.
• W303704380 modified "2023-09-25" @default.
• W303704380 title "Protection against Foreign DNA" @default.
• W303704380 cites W116448561 @default.
• W303704380 cites W1495583714 @default.
• W303704380 cites W1525072270 @default.
• W303704380 cites W1545338345 @default.
• W303704380 cites W1606572716 @default.
• W303704380 cites W1803661918 @default.
• W303704380 cites W1965404910 @default.
• W303704380 cites W1969289536 @default.
• W303704380 cites W1971374692 @default.
• W303704380 cites W1974264656 @default.
• W303704380 cites W1977531433 @default.
• W303704380 cites W1985291693 @default.
• W303704380 cites W1985963323 @default.
• W303704380 cites W1986171241 @default.
• W303704380 cites W1990487336 @default.
• W303704380 cites W1992991030 @default.
• W303704380 cites W1995425987 @default.
• W303704380 cites W1995438737 @default.
• W303704380 cites W1995867192 @default.
• W303704380 cites W2007153971 @default.
• W303704380 cites W2010986636 @default.
• W303704380 cites W2012688574 @default.
• W303704380 cites W2017721099 @default.
• W303704380 cites W2018775916 @default.
• W303704380 cites W2025070182 @default.
• W303704380 cites W2029647341 @default.
• W303704380 cites W2029926937 @default.
• W303704380 cites W2040685207 @default.
• W303704380 cites W2042843114 @default.
• W303704380 cites W2043479097 @default.
• W303704380 cites W2044892607 @default.
• W303704380 cites W2047032063 @default.
• W303704380 cites W2057964816 @default.
• W303704380 cites W2059901968 @default.
• W303704380 cites W2060573994 @default.
• W303704380 cites W2061555533 @default.
• W303704380 cites W2062139873 @default.
• W303704380 cites W2063376698 @default.
• W303704380 cites W2064177852 @default.
• W303704380 cites W2067853474 @default.
• W303704380 cites W2074478813 @default.
• W303704380 cites W2074862753 @default.
• W303704380 cites W2077190448 @default.
• W303704380 cites W2077911023 @default.
• W303704380 cites W2078115022 @default.
• W303704380 cites W2079726617 @default.
• W303704380 cites W2080698851 @default.
• W303704380 cites W2081929203 @default.
• W303704380 cites W2081938884 @default.
• W303704380 cites W2085436536 @default.
• W303704380 cites W2086142065 @default.
• W303704380 cites W2086155031 @default.
• W303704380 cites W2090176539 @default.
• W303704380 cites W2096162460 @default.
• W303704380 cites W2097415632 @default.
• W303704380 cites W2098744490 @default.
• W303704380 cites W2099392904 @default.
• W303704380 cites W2100226515 @default.
• W303704380 cites W2101788140 @default.
• W303704380 cites W2101962198 @default.
• W303704380 cites W2102827392 @default.
• W303704380 cites W2106183669 @default.
• W303704380 cites W2108101601 @default.
• W303704380 cites W2110612352 @default.
• W303704380 cites W2112909982 @default.
• W303704380 cites W2113829429 @default.
• W303704380 cites W2118746294 @default.
• W303704380 cites W2119043925 @default.
• W303704380 cites W2120183465 @default.
• W303704380 cites W2121453804 @default.
• W303704380 cites W2123836503 @default.
• W303704380 cites W2123965484 @default.
• W303704380 cites W2127391962 @default.
• W303704380 cites W2134023754 @default.
• W303704380 cites W2134558351 @default.
• W303704380 cites W2135598273 @default.
• W303704380 cites W2137721714 @default.
• W303704380 cites W2138391026 @default.
• W303704380 cites W2139544568 @default.
• W303704380 cites W2139841981 @default.
• W303704380 cites W2143922105 @default.
• W303704380 cites W2149195791 @default.
• W303704380 cites W2149230610 @default.
• W303704380 cites W2149751339 @default.
• W303704380 cites W2152420814 @default.
• W303704380 cites W2153355254 @default.
• W303704380 cites W2153537688 @default.
• W303704380 cites W2154833032 @default.
• W303704380 cites W2157413902 @default.
• W303704380 cites W2158992333 @default.
• W303704380 cites W2160174395 @default.

• next