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• W3037048265 abstract "The aim of this study was to investigate the promoter methylation status of Rasassociated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) and Suppressor of cytokine signaling 3 (SOCS3) tumor suppressor genes and evaluate the clinical utility of these genes as noninvasive, blood-based epigenetic biomarkers for the diagnosis of Prostate Cancer (PCa).A total of 41 consecutive patients and 10 healthy control groups were enrolled in the study. Pyrosequencing was performed to analyze the methylation levels of the promoter regions of the four tumor suppressor genes in patients compared to healthy controls.The promoter methylation levels of RASSF1A, MGMT, PTEN and SOCS3 did not differ between the patient and control groups. However, SOCS3 promoter methylation level was significantly higher for patients having locally advanced PCa compared to those having localizedPCa (p<0.05).Our results indicated that SOCS3 could be a useful, noninvasive blood-based epigenetic biomarker for the diagnosis of locally advanced PCa.Bu çalışmanın amacı tümör baskılayıcı genler Ras-associated domain family 1A (RASSF1A), O-6-methylguanine-DNA methyltransferase (MGMT), Phosphatase with tensin homology (PTEN) ve Suppressor of cytokine signaling 3 (SOCS3)’in promotör metilasyonlarını araştırmak ve bu genlerin Prostat Kanseri (PK) tanısı için noninvaziv, kan temelli epigenetik biyobelirteçler olarak klinik yararını değerlendirmekti.41 hasta ve 10 sağlıklı kontrol grubu çalışmaya kaydedildi. Dört tümör baskılayıcı genin promotör bölgelerinin metilasyon düzeylerini hastalarda sağlıklı kontrol grubuna kıyasla analiz etmek için pirodizileme gerçekleştirildi.RASSF1A, MGMT, PTEN ve SOCS3 promotör metilasyon düzeyleri hasta ve konrol grubu arasında farklı değildi. Ancak SOCS3 promotör metilasyon düzeyi lokalize PK’lı hastalara kıyasla lokal olarak ilerlemiş PK’lı hastalarda önemli şekilde daha yüksekti (p<0.05).Sonuçlarımız SOCS3’ün lokal olarak ilerlemiş PK tanısında elverişli, noninvaziv kan temelli epigenetik biyobelirteç olabileceğini gösterdi." @default.
• W3037048265 created "2020-07-02" @default.
• W3037048265 creator A5018184465 @default.
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• W3037048265 date "2020-01-01" @default.
• W3037048265 modified "2023-10-16" @default.
• W3037048265 title "Aberrant SOCS3 Promoter Methylation as a Noninvasive Diagnostic Biomarker for Locally Advanced Prostate Cancer" @default.
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• W3037048265 doi "https://doi.org/10.5222/mmj.2020.58708" @default.
• W3037048265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7384502" @default.
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• W3037048265 hasPublicationYear "2020" @default.
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