Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037087965> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3037087965 endingPage "62" @default.
- W3037087965 startingPage "56" @default.
- W3037087965 abstract "The use of hyaluronidase contributes to improvement in microcirculation, destruction of biofilms and reducing of congestion in patients with chronic prostatitis. Based on this mechanism, the use Longidaza for the diagnosis of latent bacterial prostatitis was suggested.To evaluate diagnostic and treatment capabilities of the long-acting enzyme preparation Longidaza (rectal suppositories with an activity of 3000 IU), prescribed to patients with chronic prostatitis in routine clinical practice.A total of 39 men with chronic prostatitis of categories II and IIIa were included in open, prospective, non-interventional, comparative, single-center study. A microbiological study of expressed prostate secretion (EPS) was performed three times, at baseline, after using two suppositories Longidaza 3000 IU and after 7 weeks of therapy. From the 1st to the 10th suppository, Longidaza was used every 48 hours, then, from the 11th to the 20th suppository, it was prescribed every 72 hours. The isolation of the pathogen was an indication for the antibiotic therapy. The treatment outcome was evaluated by using NIH-CPSI scale and laboratory and microbiological analysis of EPS.Diagnostic stage. Initially, pathogens were isolated in 27 (69.2%) patients. The number of leukocytes in EPS averaged 25.9+/-2.3. The use of two suppositories Longidaza increased the number of patients with isolated pathogens to 33 (82%). In 7 out 12 patients with an initial diagnosis of abacterial prostatitis, the use of two suppositories of Longidaza contributed to isolation of the pathogen in EPS (58.3%). The number of leukocytes in the EPS after enzymatic provocation increased by 50.2%. Treatment stage. The number of patients with isolated pathogens decreased from 33 to 7 (17.9%). The pain intensity decreased on average to 2.2+/-0.4 points, and in 27 (69.2%) men dysuria resolved. The quality of life significantly improved up to 1.3+/-0.2 points. The total score on NIH-CPSI scale decreased on average from 17.3+/-1.9 to 3.9+/-0.3 (p<0.05). An increased number of white blood cells in EPS was seen only in 5 (12.8%) men.In many cases, bacterial prostatitis remains undiagnosed. Rectal suppositories Longidaza can be recommended for the diagnosis of the latent bacterial chronic prostatitis, since this drug contributes to detection of pathogen and inflammation." @default.
- W3037087965 created "2020-07-02" @default.
- W3037087965 creator A5001215830 @default.
- W3037087965 creator A5013823903 @default.
- W3037087965 creator A5029184446 @default.
- W3037087965 creator A5041702150 @default.
- W3037087965 creator A5082326732 @default.
- W3037087965 date "2020-06-29" @default.
- W3037087965 modified "2023-10-01" @default.
- W3037087965 title "New opportunities of using gialuronidase in chronic prostatitis" @default.
- W3037087965 doi "https://doi.org/10.18565/urology.2020.3.56-62" @default.
- W3037087965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32597587" @default.
- W3037087965 hasPublicationYear "2020" @default.
- W3037087965 type Work @default.
- W3037087965 sameAs 3037087965 @default.
- W3037087965 citedByCount "4" @default.
- W3037087965 countsByYear W30370879652021 @default.
- W3037087965 countsByYear W30370879652022 @default.
- W3037087965 countsByYear W30370879652023 @default.
- W3037087965 crossrefType "journal-article" @default.
- W3037087965 hasAuthorship W3037087965A5001215830 @default.
- W3037087965 hasAuthorship W3037087965A5013823903 @default.
- W3037087965 hasAuthorship W3037087965A5029184446 @default.
- W3037087965 hasAuthorship W3037087965A5041702150 @default.
- W3037087965 hasAuthorship W3037087965A5082326732 @default.
- W3037087965 hasConcept C121608353 @default.
- W3037087965 hasConcept C126322002 @default.
- W3037087965 hasConcept C126894567 @default.
- W3037087965 hasConcept C2776235491 @default.
- W3037087965 hasConcept C2778042862 @default.
- W3037087965 hasConcept C2779529836 @default.
- W3037087965 hasConcept C2780524745 @default.
- W3037087965 hasConcept C501593827 @default.
- W3037087965 hasConcept C71924100 @default.
- W3037087965 hasConcept C86803240 @default.
- W3037087965 hasConcept C89423630 @default.
- W3037087965 hasConcept C90924648 @default.
- W3037087965 hasConcept C98274493 @default.
- W3037087965 hasConceptScore W3037087965C121608353 @default.
- W3037087965 hasConceptScore W3037087965C126322002 @default.
- W3037087965 hasConceptScore W3037087965C126894567 @default.
- W3037087965 hasConceptScore W3037087965C2776235491 @default.
- W3037087965 hasConceptScore W3037087965C2778042862 @default.
- W3037087965 hasConceptScore W3037087965C2779529836 @default.
- W3037087965 hasConceptScore W3037087965C2780524745 @default.
- W3037087965 hasConceptScore W3037087965C501593827 @default.
- W3037087965 hasConceptScore W3037087965C71924100 @default.
- W3037087965 hasConceptScore W3037087965C86803240 @default.
- W3037087965 hasConceptScore W3037087965C89423630 @default.
- W3037087965 hasConceptScore W3037087965C90924648 @default.
- W3037087965 hasConceptScore W3037087965C98274493 @default.
- W3037087965 hasLocation W30370879651 @default.
- W3037087965 hasLocation W30370879652 @default.
- W3037087965 hasOpenAccess W3037087965 @default.
- W3037087965 hasPrimaryLocation W30370879651 @default.
- W3037087965 hasRelatedWork W111292987 @default.
- W3037087965 hasRelatedWork W1456213823 @default.
- W3037087965 hasRelatedWork W1966635357 @default.
- W3037087965 hasRelatedWork W1970713749 @default.
- W3037087965 hasRelatedWork W2072824380 @default.
- W3037087965 hasRelatedWork W2103241343 @default.
- W3037087965 hasRelatedWork W2350401440 @default.
- W3037087965 hasRelatedWork W2384969752 @default.
- W3037087965 hasRelatedWork W2392395639 @default.
- W3037087965 hasRelatedWork W2614794076 @default.
- W3037087965 hasVolume "3_2020" @default.
- W3037087965 isParatext "false" @default.
- W3037087965 isRetracted "false" @default.
- W3037087965 magId "3037087965" @default.
- W3037087965 workType "article" @default.