FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037094764> ?p ?o ?g. }

• W3037094764 abstract "Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood. In the present study, we demonstrate a critical role of β-catenin-NF-κB-FPGS pathway in MTX resistance in the human T-lineage ALL cell lines.Lentivirus sh-β-catenin was used to silence the expression of β-catenin. Flow cytometry was performed to detect apoptosis after MTX treatment. Western blot, real-time PCR, Co-immunoprecipitation (Co-IP), Chromatin immunoprecipitation (ChIP), Re-ChIP, and Luciferase assay were utilized to investigate the relationship among β-catenin, nuclear factor (NF)-κB, and folypoly-γ-glutamate synthetase (FPGS).Depletion of β-catenin significantly increased the cytotoxicity of MTX. At the molecular level, knockdown of β-catenin caused the increase of the protein level of FPGS and NF-κB p65. Furthermore, β-catenin complexed with NF-κB p65 and directly bound to the FPGS promoter to regulate its expression. In addition, β-catenin repression prolonged the protein turnover of FPGS.Taken together, our results demonstrate that β-catenin may contribute to MTX resistance in leukemia cells via the β-catenin-NF-κB-FPGS pathway, posing β-catenin as a potential target for combination treatments during ALL therapy." @default.
• W3037094764 created "2020-07-02" @default.
• W3037094764 creator A5032863968 @default.
• W3037094764 creator A5048935403 @default.
• W3037094764 creator A5049154524 @default.
• W3037094764 creator A5052059747 @default.
• W3037094764 creator A5059608247 @default.
• W3037094764 creator A5087359677 @default.
• W3037094764 creator A5088034304 @default.
• W3037094764 date "2020-06-24" @default.
• W3037094764 modified "2023-09-28" @default.
• W3037094764 title "β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB" @default.
• W3037094764 cites W1600598432 @default.
• W3037094764 cites W1968622258 @default.
• W3037094764 cites W1971354029 @default.
• W3037094764 cites W1975054670 @default.
• W3037094764 cites W1983771472 @default.
• W3037094764 cites W1988423866 @default.
• W3037094764 cites W1991147726 @default.
• W3037094764 cites W1996168314 @default.
• W3037094764 cites W2008219581 @default.
• W3037094764 cites W2014012297 @default.
• W3037094764 cites W2014852322 @default.
• W3037094764 cites W2016153925 @default.
• W3037094764 cites W2016833582 @default.
• W3037094764 cites W2020018765 @default.
• W3037094764 cites W2038713860 @default.
• W3037094764 cites W2039071189 @default.
• W3037094764 cites W2042073539 @default.
• W3037094764 cites W2051481113 @default.
• W3037094764 cites W2059999488 @default.
• W3037094764 cites W2061765285 @default.
• W3037094764 cites W2062690848 @default.
• W3037094764 cites W2063124444 @default.
• W3037094764 cites W2070834113 @default.
• W3037094764 cites W2074606310 @default.
• W3037094764 cites W2082538047 @default.
• W3037094764 cites W2083020021 @default.
• W3037094764 cites W2117434167 @default.
• W3037094764 cites W2129948905 @default.
• W3037094764 cites W2145004863 @default.
• W3037094764 cites W2147139497 @default.
• W3037094764 cites W2152752097 @default.
• W3037094764 cites W2163924431 @default.
• W3037094764 cites W2179115815 @default.
• W3037094764 cites W2315613727 @default.
• W3037094764 cites W2522422641 @default.
• W3037094764 cites W2558119126 @default.
• W3037094764 cites W2921400279 @default.
• W3037094764 cites W2942545243 @default.
• W3037094764 doi "https://doi.org/10.1186/s12935-020-01364-y" @default.
• W3037094764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7313175" @default.
• W3037094764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32587478" @default.
• W3037094764 hasPublicationYear "2020" @default.
• W3037094764 type Work @default.
• W3037094764 sameAs 3037094764 @default.
• W3037094764 citedByCount "2" @default.
• W3037094764 countsByYear W30370947642021 @default.
• W3037094764 crossrefType "journal-article" @default.
• W3037094764 hasAuthorship W3037094764A5032863968 @default.
• W3037094764 hasAuthorship W3037094764A5048935403 @default.
• W3037094764 hasAuthorship W3037094764A5049154524 @default.
• W3037094764 hasAuthorship W3037094764A5052059747 @default.
• W3037094764 hasAuthorship W3037094764A5059608247 @default.
• W3037094764 hasAuthorship W3037094764A5087359677 @default.
• W3037094764 hasAuthorship W3037094764A5088034304 @default.
• W3037094764 hasBestOaLocation W30370947641 @default.
• W3037094764 hasConcept C101762097 @default.
• W3037094764 hasConcept C102658986 @default.
• W3037094764 hasConcept C104317684 @default.
• W3037094764 hasConcept C134320426 @default.
• W3037094764 hasConcept C137620995 @default.
• W3037094764 hasConcept C150194340 @default.
• W3037094764 hasConcept C153911025 @default.
• W3037094764 hasConcept C173396325 @default.
• W3037094764 hasConcept C190283241 @default.
• W3037094764 hasConcept C25602115 @default.
• W3037094764 hasConcept C30145163 @default.
• W3037094764 hasConcept C502942594 @default.
• W3037094764 hasConcept C54355233 @default.
• W3037094764 hasConcept C553184892 @default.
• W3037094764 hasConcept C55493867 @default.
• W3037094764 hasConcept C62478195 @default.
• W3037094764 hasConcept C71829478 @default.
• W3037094764 hasConcept C81885089 @default.
• W3037094764 hasConcept C86803240 @default.
• W3037094764 hasConcept C95444343 @default.
• W3037094764 hasConceptScore W3037094764C101762097 @default.
• W3037094764 hasConceptScore W3037094764C102658986 @default.
• W3037094764 hasConceptScore W3037094764C104317684 @default.
• W3037094764 hasConceptScore W3037094764C134320426 @default.
• W3037094764 hasConceptScore W3037094764C137620995 @default.
• W3037094764 hasConceptScore W3037094764C150194340 @default.
• W3037094764 hasConceptScore W3037094764C153911025 @default.
• W3037094764 hasConceptScore W3037094764C173396325 @default.
• W3037094764 hasConceptScore W3037094764C190283241 @default.
• W3037094764 hasConceptScore W3037094764C25602115 @default.
• W3037094764 hasConceptScore W3037094764C30145163 @default.
• W3037094764 hasConceptScore W3037094764C502942594 @default.
• W3037094764 hasConceptScore W3037094764C54355233 @default.

• next