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• W3037096817 abstract "Abstract Prion diseases are caused by PrP Sc , a self-replicating pathologically misfolded protein that exerts toxicity predominantly in the brain. The administration of PrP Sc causes a robust, reproducible and specific disease manifestation. Here we have applied a combination of translating ribosome affinity purification and ribosome profiling to identify biologically relevant prion-induced changes during disease progression in a cell-type specific and genome-wide manner. Terminally diseased mice with severe neurological symptoms showed extensive alterations in astrocytes and microglia. Surprisingly, we detected only minor changes in the translational profiles of neurons. Prion-induced alterations in glia overlapped with those identified in other neurodegenerative diseases, suggesting that similar events occur in a broad spectrum of pathologies. Our results suggest that aberrant translation within glia may suffice to cause severe neurological symptoms and may even be the primary driver of prion disease." @default.
• W3037096817 created "2020-07-02" @default.
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• W3037096817 date "2020-06-27" @default.
• W3037096817 modified "2023-10-18" @default.
• W3037096817 title "Prions induce minor genome-wide translational changes in neurons compared to glia" @default.
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• W3037096817 doi "https://doi.org/10.1101/2020.06.26.172841" @default.
• W3037096817 hasPublicationYear "2020" @default.
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