FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037105783> ?p ?o ?g. }

• W3037105783 endingPage "2290" @default.
• W3037105783 startingPage "2279" @default.
• W3037105783 abstract "The primary barrier that protects our lungs against infection by pathogens is a tightly sealed layer of epithelial cells. When the integrity of this barrier is disrupted as a consequence of chronic pulmonary diseases or viral insults, bacterial pathogens will gain access to underlying tissues. A major pathogen that can take advantage of such conditions is Staphylococcus aureus, thereby causing severe pneumonia. In this study, we investigated how S. aureus responds to different conditions of the human epithelium, especially nonpolarization and fibrogenesis during regeneration using an in vitro infection model. The infective process was monitored by quantification of the epithelial cell and bacterial populations, fluorescence microscopy, and mass spectrometry. The results uncover differences in bacterial internalization and population dynamics that correlate with the outcome of infection. Protein profiling reveals that, irrespective of the polarization state of the epithelial cells, the invading bacteria mount similar responses to adapt to the intracellular milieu. Remarkably, a bacterial adaptation that was associated with the regeneration state of the epithelial cells concerned the early upregulation of proteins controlled by the redox-responsive regulator Rex when bacteria were confronted with a polarized cell layer. This is indicative of the modulation of the bacterial cytoplasmic redox state to maintain homeostasis early during infection even before internalization. Our present observations provide a deeper insight into how S. aureus can take advantage of a breached epithelial barrier and show that infected epithelial cells have limited ability to respond adequately to staphylococcal insults." @default.
• W3037105783 created "2020-07-02" @default.
• W3037105783 creator A5021399548 @default.
• W3037105783 creator A5032315911 @default.
• W3037105783 creator A5049738324 @default.
• W3037105783 creator A5049849598 @default.
• W3037105783 creator A5070787254 @default.
• W3037105783 creator A5070913547 @default.
• W3037105783 creator A5073138784 @default.
• W3037105783 creator A5073207947 @default.
• W3037105783 creator A5085641552 @default.
• W3037105783 creator A5085667735 @default.
• W3037105783 date "2020-06-24" @default.
• W3037105783 modified "2023-10-14" @default.
• W3037105783 title "Interaction of <i>Staphylococcus aureus</i> and Host Cells upon Infection of Bronchial Epithelium during Different Stages of Regeneration" @default.
• W3037105783 cites W1096714769 @default.
• W3037105783 cites W1481890797 @default.
• W3037105783 cites W1482206735 @default.
• W3037105783 cites W1513972571 @default.
• W3037105783 cites W1581206428 @default.
• W3037105783 cites W1880213764 @default.
• W3037105783 cites W1965221772 @default.
• W3037105783 cites W1972703563 @default.
• W3037105783 cites W1986787331 @default.
• W3037105783 cites W1989142603 @default.
• W3037105783 cites W1999785717 @default.
• W3037105783 cites W2005644246 @default.
• W3037105783 cites W2025554668 @default.
• W3037105783 cites W2033197878 @default.
• W3037105783 cites W2036384562 @default.
• W3037105783 cites W2039290168 @default.
• W3037105783 cites W2040052393 @default.
• W3037105783 cites W2046228858 @default.
• W3037105783 cites W2055411163 @default.
• W3037105783 cites W2062859898 @default.
• W3037105783 cites W2064307892 @default.
• W3037105783 cites W2066847273 @default.
• W3037105783 cites W2079210215 @default.
• W3037105783 cites W2085999738 @default.
• W3037105783 cites W2091089657 @default.
• W3037105783 cites W2098533519 @default.
• W3037105783 cites W2101892154 @default.
• W3037105783 cites W2104947426 @default.
• W3037105783 cites W2106532565 @default.
• W3037105783 cites W2110947112 @default.
• W3037105783 cites W2112319975 @default.
• W3037105783 cites W2119016887 @default.
• W3037105783 cites W2120480075 @default.
• W3037105783 cites W2124887657 @default.
• W3037105783 cites W2126467473 @default.
• W3037105783 cites W2134203448 @default.
• W3037105783 cites W2135673226 @default.
• W3037105783 cites W2144792692 @default.
• W3037105783 cites W2146512944 @default.
• W3037105783 cites W2156294642 @default.
• W3037105783 cites W2161651529 @default.
• W3037105783 cites W2164191772 @default.
• W3037105783 cites W2168504646 @default.
• W3037105783 cites W2171721879 @default.
• W3037105783 cites W2174258440 @default.
• W3037105783 cites W2179164933 @default.
• W3037105783 cites W2181109525 @default.
• W3037105783 cites W2314649741 @default.
• W3037105783 cites W2410897757 @default.
• W3037105783 cites W2751895478 @default.
• W3037105783 cites W2770152359 @default.
• W3037105783 cites W2770806876 @default.
• W3037105783 cites W2790441421 @default.
• W3037105783 cites W2891400931 @default.
• W3037105783 cites W2917120173 @default.
• W3037105783 doi "https://doi.org/10.1021/acsinfecdis.0c00403" @default.
• W3037105783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7432605" @default.
• W3037105783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32579327" @default.
• W3037105783 hasPublicationYear "2020" @default.
• W3037105783 type Work @default.
• W3037105783 sameAs 3037105783 @default.
• W3037105783 citedByCount "4" @default.
• W3037105783 countsByYear W30371057832020 @default.
• W3037105783 countsByYear W30371057832021 @default.
• W3037105783 countsByYear W30371057832022 @default.
• W3037105783 crossrefType "journal-article" @default.
• W3037105783 hasAuthorship W3037105783A5021399548 @default.
• W3037105783 hasAuthorship W3037105783A5032315911 @default.
• W3037105783 hasAuthorship W3037105783A5049738324 @default.
• W3037105783 hasAuthorship W3037105783A5049849598 @default.
• W3037105783 hasAuthorship W3037105783A5070787254 @default.
• W3037105783 hasAuthorship W3037105783A5070913547 @default.
• W3037105783 hasAuthorship W3037105783A5073138784 @default.
• W3037105783 hasAuthorship W3037105783A5073207947 @default.
• W3037105783 hasAuthorship W3037105783A5085641552 @default.
• W3037105783 hasAuthorship W3037105783A5085667735 @default.
• W3037105783 hasBestOaLocation W30371057831 @default.
• W3037105783 hasConcept C126831891 @default.
• W3037105783 hasConcept C171056886 @default.
• W3037105783 hasConcept C18903297 @default.
• W3037105783 hasConcept C203014093 @default.
• W3037105783 hasConcept C2779489039 @default.
• W3037105783 hasConcept C523546767 @default.

• next