Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037112120> ?p ?o ?g. }
- W3037112120 abstract "Abstract Background Since December 2019, the world is experiencing an unprecedented crisis due to a novel coronavirus, SARS-CoV-2. Owing to poor understanding of pathogenicity, the virus is eluding treatment and complicating recovery. Regulatory roles of long non-coding RNAs (lncRNAs) during viral infection and associated antagonism of host antiviral immune responses has become more evident in last decade. To elucidate possible functions of lncRNAs in the COVID-19 pathobiology, we have utilized RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells. Results Our analyses uncover 21 differentially expressed lncRNAs whose functions are broadly involved in cell survival and regulation of gene expression. By network enrichment analysis we find that these lncRNAs can directly interact with differentially expressed protein-coding genes ADAR, EDN1, KYNU, MALL, TLR2 and YWHAG ; and also AKAP8L, EXOSC5, GDF15, HECTD1, LARP4B, LARP7, MIPOL1, UPF1, MOV10 and PRKAR2A , host genes that interact with SARS-CoV-2 proteins. These genes are involved in cellular signaling, metabolism, immune response and RNA homeostasis. Since lncRNAs have been known to sponge microRNAs and protect expression of upregulated genes, we also identified 9 microRNAs that are induced in viral infections; however, some lncRNAs are able to block their usual suppressive effect on overexpressed genes and consequently contribute to host defense and cell survival. Conclusions Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome and this information could drive the search for novel RNA therapeutics as a treatment option." @default.
- W3037112120 created "2020-07-02" @default.
- W3037112120 creator A5031762423 @default.
- W3037112120 creator A5035360588 @default.
- W3037112120 creator A5085609894 @default.
- W3037112120 date "2020-06-29" @default.
- W3037112120 modified "2023-09-26" @default.
- W3037112120 title "Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection" @default.
- W3037112120 cites W1499978168 @default.
- W3037112120 cites W1935845881 @default.
- W3037112120 cites W1971781109 @default.
- W3037112120 cites W1975305956 @default.
- W3037112120 cites W1980492568 @default.
- W3037112120 cites W1983011875 @default.
- W3037112120 cites W1987050385 @default.
- W3037112120 cites W1991914445 @default.
- W3037112120 cites W1996934443 @default.
- W3037112120 cites W1997980793 @default.
- W3037112120 cites W2003106829 @default.
- W3037112120 cites W2008188499 @default.
- W3037112120 cites W2008808919 @default.
- W3037112120 cites W2009107445 @default.
- W3037112120 cites W2012565727 @default.
- W3037112120 cites W2017052599 @default.
- W3037112120 cites W2017215414 @default.
- W3037112120 cites W2020911849 @default.
- W3037112120 cites W2025299909 @default.
- W3037112120 cites W2036680168 @default.
- W3037112120 cites W2038663831 @default.
- W3037112120 cites W2039620187 @default.
- W3037112120 cites W2040738201 @default.
- W3037112120 cites W2041237942 @default.
- W3037112120 cites W2046387002 @default.
- W3037112120 cites W2047376205 @default.
- W3037112120 cites W2049329312 @default.
- W3037112120 cites W2049762266 @default.
- W3037112120 cites W2057129777 @default.
- W3037112120 cites W2057689931 @default.
- W3037112120 cites W2060083739 @default.
- W3037112120 cites W2062083667 @default.
- W3037112120 cites W2062502437 @default.
- W3037112120 cites W2065130054 @default.
- W3037112120 cites W2065821999 @default.
- W3037112120 cites W2071271349 @default.
- W3037112120 cites W2072191991 @default.
- W3037112120 cites W2097065948 @default.
- W3037112120 cites W2102018304 @default.
- W3037112120 cites W2102046040 @default.
- W3037112120 cites W2103828631 @default.
- W3037112120 cites W2104901753 @default.
- W3037112120 cites W2110161909 @default.
- W3037112120 cites W2110905563 @default.
- W3037112120 cites W2124828758 @default.
- W3037112120 cites W2126014959 @default.
- W3037112120 cites W2127999190 @default.
- W3037112120 cites W2128471695 @default.
- W3037112120 cites W2130687298 @default.
- W3037112120 cites W2132388686 @default.
- W3037112120 cites W2140084702 @default.
- W3037112120 cites W2140658527 @default.
- W3037112120 cites W2141877163 @default.
- W3037112120 cites W2145078103 @default.
- W3037112120 cites W2151565551 @default.
- W3037112120 cites W2152239989 @default.
- W3037112120 cites W2152310279 @default.
- W3037112120 cites W2154253535 @default.
- W3037112120 cites W2154537630 @default.
- W3037112120 cites W2156891661 @default.
- W3037112120 cites W2157399331 @default.
- W3037112120 cites W2159675211 @default.
- W3037112120 cites W2160963971 @default.
- W3037112120 cites W2161221049 @default.
- W3037112120 cites W2164516553 @default.
- W3037112120 cites W2168909179 @default.
- W3037112120 cites W2172312226 @default.
- W3037112120 cites W2229093700 @default.
- W3037112120 cites W2291209850 @default.
- W3037112120 cites W2309148697 @default.
- W3037112120 cites W2388201280 @default.
- W3037112120 cites W2493102442 @default.
- W3037112120 cites W2580888383 @default.
- W3037112120 cites W2591199714 @default.
- W3037112120 cites W2617324043 @default.
- W3037112120 cites W2735527928 @default.
- W3037112120 cites W2748135921 @default.
- W3037112120 cites W2786987313 @default.
- W3037112120 cites W2794298491 @default.
- W3037112120 cites W2798118914 @default.
- W3037112120 cites W2805978177 @default.
- W3037112120 cites W2810124351 @default.
- W3037112120 cites W2888987199 @default.
- W3037112120 cites W2889623518 @default.
- W3037112120 cites W2891009119 @default.
- W3037112120 cites W2895829670 @default.
- W3037112120 cites W2898331278 @default.
- W3037112120 cites W2900569176 @default.
- W3037112120 cites W2900980455 @default.
- W3037112120 cites W2902220381 @default.
- W3037112120 cites W2909077044 @default.
- W3037112120 cites W2914948784 @default.