Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037121760> ?p ?o ?g. }
- W3037121760 endingPage "500" @default.
- W3037121760 startingPage "491" @default.
- W3037121760 abstract "Background: Mortality from COVID-19 is high among hospitalized patients and effective therapeutics are lacking. Hypercoagulability, thrombosis and hyperinflammation occur in COVID-19 and may contribute to severe complications. Therapeutic anticoagulation may improve clinical outcomes through anti-thrombotic, anti-inflammatory and anti-viral mechanisms. Our primary objective is to evaluate whether therapeutic-dose anticoagulation with low-molecular-weight heparin or unfractionated heparin prevents mechanical ventilation and/or death in patients hospitalized with COVID-19 compared to usual care. Methods: An international, open-label, adaptive randomized controlled trial. Using a Bayesian framework, the trial will declare results as soon as pre-specified posterior probabilities for superiority, futility, or harm are reached. The trial uses response-adaptive randomization to maximize the probability that patients will receive the more beneficial treatment approach, as treatment effect information accumulates within the trial. By leveraging a common data safety monitoring board and pooling data with a second similar international Bayesian adaptive trial (REMAP-COVID anticoagulation domain), treatment efficacy and safety will be evaluated as efficiently as possible. The primary outcome is an ordinal endpoint with three possible outcomes based on the worst status of each patient through day 30: no requirement for invasive mechanical ventilation, invasive mechanical ventilation or death. Conclusion: Using an adaptive trial design, the Anti-Thrombotic Therapy To Ameliorate Complications of COVID-19 trial will establish whether therapeutic anticoagulation can reduce mortality and/or avoid the need for mechanical ventilation in patients hospitalized with COVID-19. Leveraging existing networks to recruit sites will increase enrollment and mitigate enrollment risk in sites with declining COVID-19 cases." @default.
- W3037121760 created "2020-07-02" @default.
- W3037121760 creator A5000380712 @default.
- W3037121760 creator A5004322015 @default.
- W3037121760 creator A5006536000 @default.
- W3037121760 creator A5015444962 @default.
- W3037121760 creator A5021959578 @default.
- W3037121760 creator A5025028312 @default.
- W3037121760 creator A5029744589 @default.
- W3037121760 creator A5032923204 @default.
- W3037121760 creator A5034441524 @default.
- W3037121760 creator A5035524531 @default.
- W3037121760 creator A5039409201 @default.
- W3037121760 creator A5040595008 @default.
- W3037121760 creator A5041519561 @default.
- W3037121760 creator A5043621364 @default.
- W3037121760 creator A5043765709 @default.
- W3037121760 creator A5044527590 @default.
- W3037121760 creator A5053987402 @default.
- W3037121760 creator A5054511215 @default.
- W3037121760 creator A5060465607 @default.
- W3037121760 creator A5061855694 @default.
- W3037121760 creator A5065187538 @default.
- W3037121760 creator A5065441662 @default.
- W3037121760 creator A5068248121 @default.
- W3037121760 creator A5069849817 @default.
- W3037121760 creator A5070604004 @default.
- W3037121760 creator A5077857331 @default.
- W3037121760 creator A5086810447 @default.
- W3037121760 date "2020-08-20" @default.
- W3037121760 modified "2023-09-27" @default.
- W3037121760 title "Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study design and methodology for an international, adaptive Bayesian randomized controlled trial" @default.
- W3037121760 cites W1969165345 @default.
- W3037121760 cites W2036260951 @default.
- W3037121760 cites W2038032151 @default.
- W3037121760 cites W2080086845 @default.
- W3037121760 cites W2085634119 @default.
- W3037121760 cites W2103908189 @default.
- W3037121760 cites W2131663716 @default.
- W3037121760 cites W2158075034 @default.
- W3037121760 cites W2160524382 @default.
- W3037121760 cites W2398242977 @default.
- W3037121760 cites W2468673334 @default.
- W3037121760 cites W2989714602 @default.
- W3037121760 cites W3001897055 @default.
- W3037121760 cites W3006354146 @default.
- W3037121760 cites W3007092620 @default.
- W3037121760 cites W3008461878 @default.
- W3037121760 cites W3008827533 @default.
- W3037121760 cites W3009859788 @default.
- W3037121760 cites W3013486442 @default.
- W3037121760 cites W3015490759 @default.
- W3037121760 cites W3015946392 @default.
- W3037121760 cites W3016595631 @default.
- W3037121760 cites W3021954309 @default.
- W3037121760 cites W3022564719 @default.
- W3037121760 cites W3027630905 @default.
- W3037121760 cites W3165656738 @default.
- W3037121760 doi "https://doi.org/10.1177/1740774520943846" @default.
- W3037121760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32815416" @default.
- W3037121760 hasPublicationYear "2020" @default.
- W3037121760 type Work @default.
- W3037121760 sameAs 3037121760 @default.
- W3037121760 citedByCount "53" @default.
- W3037121760 countsByYear W30371217602020 @default.
- W3037121760 countsByYear W30371217602021 @default.
- W3037121760 countsByYear W30371217602022 @default.
- W3037121760 countsByYear W30371217602023 @default.
- W3037121760 crossrefType "journal-article" @default.
- W3037121760 hasAuthorship W3037121760A5000380712 @default.
- W3037121760 hasAuthorship W3037121760A5004322015 @default.
- W3037121760 hasAuthorship W3037121760A5006536000 @default.
- W3037121760 hasAuthorship W3037121760A5015444962 @default.
- W3037121760 hasAuthorship W3037121760A5021959578 @default.
- W3037121760 hasAuthorship W3037121760A5025028312 @default.
- W3037121760 hasAuthorship W3037121760A5029744589 @default.
- W3037121760 hasAuthorship W3037121760A5032923204 @default.
- W3037121760 hasAuthorship W3037121760A5034441524 @default.
- W3037121760 hasAuthorship W3037121760A5035524531 @default.
- W3037121760 hasAuthorship W3037121760A5039409201 @default.
- W3037121760 hasAuthorship W3037121760A5040595008 @default.
- W3037121760 hasAuthorship W3037121760A5041519561 @default.
- W3037121760 hasAuthorship W3037121760A5043621364 @default.
- W3037121760 hasAuthorship W3037121760A5043765709 @default.
- W3037121760 hasAuthorship W3037121760A5044527590 @default.
- W3037121760 hasAuthorship W3037121760A5053987402 @default.
- W3037121760 hasAuthorship W3037121760A5054511215 @default.
- W3037121760 hasAuthorship W3037121760A5060465607 @default.
- W3037121760 hasAuthorship W3037121760A5061855694 @default.
- W3037121760 hasAuthorship W3037121760A5065187538 @default.
- W3037121760 hasAuthorship W3037121760A5065441662 @default.
- W3037121760 hasAuthorship W3037121760A5068248121 @default.
- W3037121760 hasAuthorship W3037121760A5069849817 @default.
- W3037121760 hasAuthorship W3037121760A5070604004 @default.
- W3037121760 hasAuthorship W3037121760A5077857331 @default.
- W3037121760 hasAuthorship W3037121760A5086810447 @default.
- W3037121760 hasBestOaLocation W30371217602 @default.
- W3037121760 hasConcept C126322002 @default.