Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037177777> ?p ?o ?g. }
- W3037177777 endingPage "553" @default.
- W3037177777 startingPage "553" @default.
- W3037177777 abstract "This study determined whether antioxidant supplementation is a viable complement to exercise regimens in improving cognitive and motor performance in a mouse model of Alzheimer’s disease risk. Starting at 12 months of age, separate groups of male and female mice expressing human Apolipoprotein E3 (GFAP-ApoE3) or E4 (GFAP-ApoE4) were fed either a control diet or a diet supplemented with vitamins E and C. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure reflex and motor, cognitive, and affective function while remaining on their treatment. Subsequently, plasma inflammatory markers and catalase activity in brain regions were measured. Overall, the GFAP-ApoE4 mice exhibited poorer motor function and spatial learning and memory. The treatments improved balance, learning, and cognitive flexibility in the GFAP-ApoE3 mice and overall the GFAP-ApoE4 mice were not responsive. The addition of antioxidants to supplement a training regimen only provided further benefits to the active avoidance task, and there was no antagonistic interaction between the two interventions. These outcomes are indicative that there is a window of opportunity for treatment and that genotype plays an important role in response to interventions." @default.
- W3037177777 created "2020-07-02" @default.
- W3037177777 creator A5019693747 @default.
- W3037177777 creator A5032136445 @default.
- W3037177777 creator A5059630674 @default.
- W3037177777 creator A5073698677 @default.
- W3037177777 creator A5084390401 @default.
- W3037177777 creator A5085618024 @default.
- W3037177777 date "2020-06-25" @default.
- W3037177777 modified "2023-09-27" @default.
- W3037177777 title "ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function" @default.
- W3037177777 cites W1482965374 @default.
- W3037177777 cites W1582047578 @default.
- W3037177777 cites W1617441945 @default.
- W3037177777 cites W1889306845 @default.
- W3037177777 cites W1961745697 @default.
- W3037177777 cites W1965031379 @default.
- W3037177777 cites W1966362676 @default.
- W3037177777 cites W1968106485 @default.
- W3037177777 cites W1969140956 @default.
- W3037177777 cites W1976494740 @default.
- W3037177777 cites W1981395387 @default.
- W3037177777 cites W1985410153 @default.
- W3037177777 cites W1986733770 @default.
- W3037177777 cites W1995876047 @default.
- W3037177777 cites W2016719751 @default.
- W3037177777 cites W2017595192 @default.
- W3037177777 cites W2028185853 @default.
- W3037177777 cites W2036092569 @default.
- W3037177777 cites W2038242814 @default.
- W3037177777 cites W2045622306 @default.
- W3037177777 cites W2052006054 @default.
- W3037177777 cites W2053770559 @default.
- W3037177777 cites W2056609024 @default.
- W3037177777 cites W2058138985 @default.
- W3037177777 cites W2059182065 @default.
- W3037177777 cites W2071402888 @default.
- W3037177777 cites W2077955123 @default.
- W3037177777 cites W2100498504 @default.
- W3037177777 cites W2103550756 @default.
- W3037177777 cites W2105683279 @default.
- W3037177777 cites W2106067304 @default.
- W3037177777 cites W2109527205 @default.
- W3037177777 cites W2114887688 @default.
- W3037177777 cites W2117396891 @default.
- W3037177777 cites W2117866456 @default.
- W3037177777 cites W2130449421 @default.
- W3037177777 cites W2130714847 @default.
- W3037177777 cites W2131922688 @default.
- W3037177777 cites W2132522309 @default.
- W3037177777 cites W2142350129 @default.
- W3037177777 cites W2150122398 @default.
- W3037177777 cites W2154465038 @default.
- W3037177777 cites W2156140272 @default.
- W3037177777 cites W2158662933 @default.
- W3037177777 cites W2159579257 @default.
- W3037177777 cites W2163853090 @default.
- W3037177777 cites W2168467955 @default.
- W3037177777 cites W2282500397 @default.
- W3037177777 cites W2287584360 @default.
- W3037177777 cites W2306696647 @default.
- W3037177777 cites W2327790265 @default.
- W3037177777 cites W2403424502 @default.
- W3037177777 cites W2792455259 @default.
- W3037177777 cites W2801948587 @default.
- W3037177777 cites W2890777607 @default.
- W3037177777 cites W2896286917 @default.
- W3037177777 cites W2905067650 @default.
- W3037177777 cites W2925302935 @default.
- W3037177777 cites W2995103144 @default.
- W3037177777 cites W3011960079 @default.
- W3037177777 cites W3016417418 @default.
- W3037177777 cites W3028248106 @default.
- W3037177777 doi "https://doi.org/10.3390/antiox9060553" @default.
- W3037177777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7346214" @default.
- W3037177777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32630431" @default.
- W3037177777 hasPublicationYear "2020" @default.
- W3037177777 type Work @default.
- W3037177777 sameAs 3037177777 @default.
- W3037177777 citedByCount "3" @default.
- W3037177777 countsByYear W30371777772022 @default.
- W3037177777 countsByYear W30371777772023 @default.
- W3037177777 crossrefType "journal-article" @default.
- W3037177777 hasAuthorship W3037177777A5019693747 @default.
- W3037177777 hasAuthorship W3037177777A5032136445 @default.
- W3037177777 hasAuthorship W3037177777A5059630674 @default.
- W3037177777 hasAuthorship W3037177777A5073698677 @default.
- W3037177777 hasAuthorship W3037177777A5084390401 @default.
- W3037177777 hasAuthorship W3037177777A5085618024 @default.
- W3037177777 hasBestOaLocation W30371777771 @default.
- W3037177777 hasConcept C113062710 @default.
- W3037177777 hasConcept C118552586 @default.
- W3037177777 hasConcept C126322002 @default.
- W3037177777 hasConcept C134018914 @default.
- W3037177777 hasConcept C15744967 @default.
- W3037177777 hasConcept C169760540 @default.
- W3037177777 hasConcept C169900460 @default.
- W3037177777 hasConcept C27415008 @default.