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- W3037179364 abstract "TYPE: Abstract Publication TOPIC: Chest Infections PURPOSE: Our objective was to evaluate the veracity of the serum total cortisol level as a biomarker for assessing the severity of CAP. METHODS: It is a descriptive and prospective study of patients with CAP admitted in the Chest Department of Assiut University Hospital between October 2017 and January 2019. The CAP severity was assessed for all enrolled patients by the pneumonia severity index (PSI) . Serum total cortisol level was measured once in the morning (between 7 am and 8 am) within the first 24 hours after admission .All of the patients were followed up until being discharged.The outcome variable was the in-hospital mortality RESULTS: The current research enrolled 94 patients with community acquired pneumonia (CAP), out of 94 patients, 62 (56%) patients survived while 32 (44%) patients deteriorated and died. The non-survivors had significantly higher serum cortisol level compared to the survivors(34.15 ± 9.78 vs. 24.90 ± 8.89; P= 0.04). Out of 94 pstients; 37 (39.4%) patients had normal cortisol level, while 57 (60.6%) had high cortisol level. Patients with high cortisol level had a significantly higher PSI (140.75 ± 48.31 vs. 103.56 ± 43.57). Serum cortisol level had positive significant correlation with PSI points (r= 0.45, P= 0.01). Serum cortisol at cut off point > 43 μg / dl had 80% sensitivity and 91% specificity to predict the in-hospital mortality in CAP patients. CONCLUSIONS: In conclusion, the serum cortisol could be considered as a promising biomarker that is able to predict the severity and outcome of CAP. CLINICAL IMPLICATIONS: To improve CAP outcome DISCLOSURE: No significant relationships. KEYWORDS: serum cortisol, serum, cortisol, CAP, serum, cortisol" @default.
- W3037179364 created "2020-07-02" @default.
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- W3037179364 date "2020-06-01" @default.
- W3037179364 modified "2023-09-27" @default.
- W3037179364 title "SERUM CORTISOL AS A BIOMARKER IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA AT ASSIUT UNIVERSITY UNIVERSITY HOSPITAL" @default.
- W3037179364 doi "https://doi.org/10.1016/j.chest.2020.05.059" @default.
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