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- W3037194019 abstract "Abstract Targeting areas of inflammation offers potential therapeutic and diagnostic benefits by maximizing drug and imaging marker on‐target effects while minimizing systemic exposure that can be associated with adverse side effects. This strategy is particularly beneficial in the management of inflammatory bowel disease (IBD). Here an inflammation‐targeting (IT) approach based on heparin‐coated human serum albumin nanoparticles (HEP‐HSA NPs) that utilize the increased intestinal permeability and changes in electrostatic interaction at the site of intestinal inflammation is described. Using small‐molecule and biologic drugs as a model for drug combination, the HEP‐HSA NPs demonstrate the capacity to load both drugs simultaneously; the dual‐drug loaded HEP‐HSA NPs exhibit a higher anti‐inflammatory effect than both of the single‐drug loaded NPs in vitro and selectively bind to inflamed intestine after enema administration in vivo in a murine model of colitis. Importantly, analyses of the physicochemical characteristics and targeting capacities of these NPs indicate that HEP coating modulates NP binding to the inflamed intestine, providing a foundation for future IT‐NP formulation development." @default.
- W3037194019 created "2020-07-02" @default.
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- W3037194019 date "2020-06-29" @default.
- W3037194019 modified "2023-10-09" @default.
- W3037194019 title "Heparin‐Coated Albumin Nanoparticles for Drug Combination in Targeting Inflamed Intestine" @default.
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- W3037194019 doi "https://doi.org/10.1002/adhm.202000536" @default.
- W3037194019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7482138" @default.
- W3037194019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32597571" @default.
- W3037194019 hasPublicationYear "2020" @default.
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