Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037200036> ?p ?o ?g. }
- W3037200036 abstract "ABSTRACT Biological membranes form the functional, dynamic interface that hosts a major fraction of all cellular bioactivity. Proper membrane physiology requires maintenance of a narrow range of physicochemical properties, which must be buffered from external perturbations. While homeostatic adaptation of membrane fluidity to temperature variation is a ubiquitous design feature of ectothermic organisms, such responsive membrane adaptation to external inputs has not been directly observed in mammals. Here, we report that challenging mammalian membrane homeostasis by dietary lipids leads to robust lipidomic remodeling to preserve membrane physical properties. Specifically, exogenous polyunsaturated fatty acids (PUFAs) are rapidly and extensively incorporated into membrane lipids, inducing a reduction in membrane packing. These effects are rapidly compensated both in culture and in vivo by lipidome-wide remodeling, most notably upregulation of saturated lipids and cholesterol. These lipidomic changes result in recovery of membrane packing and permeability. This lipidomic and biophysical compensation is mediated in part by lipid regulatory machinery, whose pharmacological or genetic abrogation results in cytotoxicity when membrane homeostasis is challenged by dietary lipids. These results reveal an essential mammalian mechanism for membrane homeostasis wherein lipidome remodeling in response to dietary lipid inputs preserves functional membrane phenotypes." @default.
- W3037200036 created "2020-07-02" @default.
- W3037200036 creator A5003522233 @default.
- W3037200036 creator A5019568866 @default.
- W3037200036 creator A5027385934 @default.
- W3037200036 creator A5044078326 @default.
- W3037200036 creator A5055819913 @default.
- W3037200036 creator A5062938584 @default.
- W3037200036 creator A5073405503 @default.
- W3037200036 date "2018-06-08" @default.
- W3037200036 modified "2023-10-07" @default.
- W3037200036 title "Lipidomic and biophysical homeostasis of mammalian membranes in response to dietary lipids is essential for cellular fitness" @default.
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