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- W3037222433 abstract "CXCL13-producing PD-1hiCXCR5−CD4+ T cells were discovered in synovial tissues of rheumatoid arthritis (RA). Further intensive analysis of RA samples led to the proposal of PD-1hiCXCR5−CD4+ T cells as a pathogenic CD4 subset, peripheral helper T (Tph) cells. Tph cells are upregulated also in the peripheral blood of seropositive RA patient and exert B-cell helper activities. Furthermore, Tph cells are associated with other inflammatory conditions including systemic lupus erythematosus, IgG4-related diseases, type 1 diabetes, inflammatory bowel diseases, and malignant tumors. In this review, molecular feature and pathogenic and beneficial functions of Tph cells in inflammatory conditions are discussed." @default.
- W3037222433 created "2020-07-02" @default.
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- W3037222433 date "2020-06-25" @default.
- W3037222433 modified "2023-09-24" @default.
- W3037222433 title "CXCL13-producing PD-1<sup>hi</sup>CXCR5<sup>−</sup> helper T cells in chronic inflammation" @default.
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- W3037222433 doi "https://doi.org/10.1080/25785826.2020.1781998" @default.
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