FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037226334> ?p ?o ?g. }

• W3037226334 endingPage "1007" @default.
• W3037226334 startingPage "993" @default.
• W3037226334 abstract "Carboxylesterase (CES) 1 is the predominant esterase expressed in the human liver and is capable of catalyzing the hydrolysis of a wide range of therapeutic agents, toxins, and endogenous compounds. Accumulating studies have demonstrated associations between the expression and activity of CES1 and the pharmacokinetics and/or pharmacodynamics of CES1 substrate medications (e.g., methylphenidate, clopidogrel, oseltamivir). Therefore, any perturbation of CES1 by coingested xenobiotics could potentially compromise treatment. Natural products are known to alter drug disposition by modulating cytochrome P450 and UDP-glucuronosyltransferase enzymes, but this issue is less thoroughly explored with CES1. We report the results of a systematic literature search and discuss natural products as potential modulators of CES1 activity. The majority of research reports reviewed were in vitro investigations that require further confirmation through clinical study. Cannabis products (<i>Δ</i>⁹-tetrahydrocannabinol, cannabidiol, cannabinol); supplements from various plant sources containing naringenin, quercetin, luteolin, oleanolic acid, and asiatic acid; and certain traditional medicines (danshen and zhizhuwan) appear to pose the highest inhibition potential. In addition, ursolic acid, gambogic acid, and glycyrrhetic acid, if delivered intravenously, may attain high enough systemic concentrations to significantly inhibit CES1. The provision of a translational interpretation of in vitro assessments of natural product actions and interactions is limited by the dearth of basic pharmacokinetic data of the natural compounds exhibiting potent in vitro influences on CES1 activity. This is a major impediment to assigning even potential clinical significance. The modulatory effects on CES1 expression after chronic exposure to natural products warrants further investigation. <h3>SIGNIFICANCE STATEMENT</h3> Modulation of CES1 activity by natural products may alter the course of treatment and clinical outcome. In this review, we have summarized the natural products that can potentially interact with CES1 substrate medications. We have also noted the limitations of existing reports and outlined challenges and future directions in this field." @default.
• W3037226334 created "2020-07-02" @default.
• W3037226334 creator A5027522542 @default.
• W3037226334 creator A5031651486 @default.
• W3037226334 date "2020-06-26" @default.
• W3037226334 modified "2023-09-26" @default.
• W3037226334 title "Natural Products as Modulators of CES1 Activity" @default.
• W3037226334 cites W1524075985 @default.
• W3037226334 cites W1718807171 @default.
• W3037226334 cites W1891787316 @default.
• W3037226334 cites W1953048298 @default.
• W3037226334 cites W1956427344 @default.
• W3037226334 cites W1958190914 @default.
• W3037226334 cites W1969084293 @default.
• W3037226334 cites W1971627099 @default.
• W3037226334 cites W1974457902 @default.
• W3037226334 cites W1976795511 @default.
• W3037226334 cites W1977055725 @default.
• W3037226334 cites W1978840408 @default.
• W3037226334 cites W1978975287 @default.
• W3037226334 cites W1979085814 @default.
• W3037226334 cites W1979228136 @default.
• W3037226334 cites W1983636271 @default.
• W3037226334 cites W1984872960 @default.
• W3037226334 cites W1988850558 @default.
• W3037226334 cites W1992475241 @default.
• W3037226334 cites W1994664425 @default.
• W3037226334 cites W1995803433 @default.
• W3037226334 cites W1996581644 @default.
• W3037226334 cites W1996833529 @default.
• W3037226334 cites W1998213002 @default.
• W3037226334 cites W2001418848 @default.
• W3037226334 cites W2002076503 @default.
• W3037226334 cites W2009046676 @default.
• W3037226334 cites W2012985982 @default.
• W3037226334 cites W2018731564 @default.
• W3037226334 cites W2023176765 @default.
• W3037226334 cites W2026314386 @default.
• W3037226334 cites W2026744291 @default.
• W3037226334 cites W2028339911 @default.
• W3037226334 cites W2030081449 @default.
• W3037226334 cites W2031084589 @default.
• W3037226334 cites W2037248257 @default.
• W3037226334 cites W2042390710 @default.
• W3037226334 cites W2054620293 @default.
• W3037226334 cites W2061397286 @default.
• W3037226334 cites W2062269191 @default.
• W3037226334 cites W2072551239 @default.
• W3037226334 cites W2076985436 @default.
• W3037226334 cites W2079946293 @default.
• W3037226334 cites W2080837408 @default.
• W3037226334 cites W2085366464 @default.
• W3037226334 cites W2091582819 @default.
• W3037226334 cites W2092661856 @default.
• W3037226334 cites W2096772371 @default.
• W3037226334 cites W2098582456 @default.
• W3037226334 cites W2102608266 @default.
• W3037226334 cites W2110202376 @default.
• W3037226334 cites W2110454194 @default.
• W3037226334 cites W2111578747 @default.
• W3037226334 cites W2111797455 @default.
• W3037226334 cites W2112810463 @default.
• W3037226334 cites W2114591238 @default.
• W3037226334 cites W2114992089 @default.
• W3037226334 cites W2115781555 @default.
• W3037226334 cites W2119895547 @default.
• W3037226334 cites W2133955411 @default.
• W3037226334 cites W2134806571 @default.
• W3037226334 cites W2137625272 @default.
• W3037226334 cites W2138577236 @default.
• W3037226334 cites W2139185290 @default.
• W3037226334 cites W2139287440 @default.
• W3037226334 cites W2141256777 @default.
• W3037226334 cites W2142291582 @default.
• W3037226334 cites W2144843569 @default.
• W3037226334 cites W2145369111 @default.
• W3037226334 cites W2147466472 @default.
• W3037226334 cites W2148588414 @default.
• W3037226334 cites W2153268417 @default.
• W3037226334 cites W2155842706 @default.
• W3037226334 cites W2159722117 @default.
• W3037226334 cites W2167972036 @default.
• W3037226334 cites W2168213856 @default.
• W3037226334 cites W2168693816 @default.
• W3037226334 cites W2169983155 @default.
• W3037226334 cites W2170258455 @default.
• W3037226334 cites W2170958988 @default.
• W3037226334 cites W2171503950 @default.
• W3037226334 cites W2171836350 @default.
• W3037226334 cites W2180851902 @default.
• W3037226334 cites W2234445748 @default.
• W3037226334 cites W2323698282 @default.
• W3037226334 cites W2331086861 @default.
• W3037226334 cites W2531420938 @default.
• W3037226334 cites W2580981584 @default.
• W3037226334 cites W2605976708 @default.
• W3037226334 cites W2623759600 @default.
• W3037226334 cites W2625333171 @default.

• next