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- W3037228412 abstract "Abstract The intracellular chloride concentration [Cl−]i in neurons is regulated by a set of transmembrane transporters, with the Cl−-loader NKCC1 and the Cl−-extruder KCC2 as most relevant members. The expression of these transporters is tightly regulated, with the general trend that KCC2 expression is low in immature neurons, which are thus characterized by a high [Cl−]i. As [Cl−]i is the main factor determining the polarity of GABAergic responses, such a high [Cl−]i is related to depolarizing GABAergic responses. However, depolarizing GABAergic responses are not per se excitatory, but can also contribute to shunting inhibition. The excitatory/inhibitory action of GABAergic responses is mainly determined by the relation between GABA reversal potential and action potential threshold, with additional conditions, like spatial confounds or voltage dependent currents, also contributing to this distinction. Accordingly, both excitatory and inhibitory GABAergic responses have been observed in immature neurons." @default.
- W3037228412 created "2020-07-02" @default.
- W3037228412 creator A5035396519 @default.
- W3037228412 date "2020-01-01" @default.
- W3037228412 modified "2023-09-26" @default.
- W3037228412 title "The relation between neuronal chloride transporter activities, GABA inhibition, and neuronal activity" @default.
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- W3037228412 doi "https://doi.org/10.1016/b978-0-12-815318-5.00003-0" @default.
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