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- W3037229738 abstract "The quinolactacins are a family of pyrroloquinoline-type natural products from Penicillium sp. From the organic extract of Penicillium sp. ENP701 fermentation broth, a microorganism from the east China sea, one new quinolactacin was isolated and named quinolactacin-H. The structure of quinolactacin-H was determined by spectroscopic analysis and the absolute configurations by X-ray crystallographic analysis. Enantioselective total synthesis of (R)-(+)-quinolactacin-H and (S)-(-)-quinolactacin-H was achieved. When assayed through crystal violet (CV) microtiter plate biofilm, both (R) and (S)-quinolactacin-H showed a strong inhibition and dispersion of Pseudomonas aeruginosa PAO1 biofilms. Thus, quinolactacins could be proposed and developed as natural anti-bioflm agents in order to solve the problem of microbial resistance in future." @default.
- W3037229738 created "2020-07-02" @default.
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- W3037229738 date "2020-01-01" @default.
- W3037229738 modified "2023-10-14" @default.
- W3037229738 title "Total synthesis of quinolactacin-H from marine-derived <i>Penicillium</i> sp. ENP701 and biological activities" @default.
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- W3037229738 doi "https://doi.org/10.1039/d0ra05244b" @default.
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