Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037249625> ?p ?o ?g. }
- W3037249625 abstract "Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits necessary for pandemic potential are poorly understood. For swine influenza viruses isolated in 2009–2016, gamma-clade viruses had less stable HA proteins (activation pH 5.5–5.9) than pandemic clade (pH 5.0–5.5). Gamma-clade viruses replicated to higher levels in mammalian cells than pandemic clade. In ferrets, a model for human adaptation, a relatively stable HA protein (pH 5.5–5.6) was necessary for efficient replication and airborne transmission. The overall airborne transmission frequency in ferrets for four isolates tested was 42%, and isolate G15 airborne transmitted 100% after selection of a variant with a stabilized HA. The results suggest swine influenza viruses containing both a stabilized HA and alpha-2,6 receptor binding in tandem pose greater pandemic risk. Increasing evidence supports adding HA stability to pre-pandemic risk assessment algorithms." @default.
- W3037249625 created "2020-07-02" @default.
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- W3037249625 date "2020-06-30" @default.
- W3037249625 modified "2023-10-06" @default.
- W3037249625 title "HA stabilization promotes replication and transmission of swine H1N1 gamma influenza viruses in ferrets" @default.
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- W3037249625 doi "https://doi.org/10.7554/elife.56236" @default.
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