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• W3037272854 startingPage "6171" @default.
• W3037272854 abstract "Circular RNAs (circRNAs) play a key role in cancer development and progression. Previously, circ_0005394 was found to be highly expressed in hepatocellular carcinoma (HCC) screened by circRNA microarray. However, the research with regard to the functions and mechanisms of circ_0005394 in HCC remains unknown.The expression of circ_0005394 in HCC was measured by qRT-PCR. The clinical relevance was evaluated by Fisher's exact test, Kaplan-Meier curves, and Cox regression model. Gain/loss-of function assays were performed to elucidate the functions of circ_0005394 in Huh-7 and HepG2 cells. Dual-luciferase reporter assay was applied to reveal the mechanism of circ_0005394.circ_0005394 expression was higher in HCC tissues and cells than noncancerous samples and normal cell line, respectively. High expression of circ_0005394 was associated with larger tumor size, more advanced TNM stages, and poorer overall survival for the patients with HCC. Gain/loss-of function assays demonstrated its oncogenic role in cell growth, apoptosis, migration, and invasion. Mechanistically, miR-507 and miR-515-5p could be sponged by circ_0005394. Furthermore, E2F Transcription Factor 3 (E2F3) and C-X-C motif chemokine ligand 6 (CXCL6) were confirmed as the target of miR-507 and miR-515-5p, respectively. Rescue assay indicated that circ_0005394 facilitated HCC growth and invasion by regulating miR-507/E2F3 and miR-515-5p/CXCL6 signaling pathways.This study uncovered an important role of circ_0005394 in regulating HCC progression, providing a novel perspective for clarifying its pathogenesis." @default.
• W3037272854 created "2020-07-02" @default.
• W3037272854 creator A5019056174 @default.
• W3037272854 creator A5027334799 @default.
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• W3037272854 date "2020-06-01" @default.
• W3037272854 modified "2023-10-16" @default.
• W3037272854 title "<p>A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways</p>" @default.
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• W3037272854 doi "https://doi.org/10.2147/ott.s256238" @default.
• W3037272854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7334013" @default.
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• W3037272854 hasPublicationYear "2020" @default.
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