FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037287210> ?p ?o ?g. }

• W3037287210 endingPage "344" @default.
• W3037287210 startingPage "338" @default.
• W3037287210 abstract "Asthma inflammation may feature an imbalance between oxidative stress and antioxidant defenses. Oxidative stress induces propagation of airways inflammation and corticosteroid insensitivity contributing to poor asthma control, and frequent severe acute exacerbations. This study assessed inflammation and oxidative stress in severe asthmatic subjects and evaluated the possible correlations between inflammatory and oxidative stress markers investigated and asthma severity. Fifty-three patients with severe asthma, 11 patients with mild-moderate asthma and 12 healthy subjects were enrolled and underwent fractional exhaled nitric oxide (FENO) analysis and blood and sputum count cell collection. The content of mitochondrial DNA (MtDNA) and nuclear DNA (nDNA) was measured in exhaled breath condensate (EBC) by Real Time PCR and the ratio between MtDNA/nDNA was calculated. We detected MtDNA/nDNA in the EBC of severe asthmatics. We found higher exhaled MtDNA/nDNA in severe asthmatics respectively compared to mild-moderate ones and to healthy controls (10.4 ± 2.2 vs 7.9 ± 2.5, p < 0.05 and 10.4 ± 2.2 vs 6.51 ± 0.21, p < 0.05). The level of exhaled MtDNA/nDNA was significantly higher in Non-T2 endotype severe asthmatics than T2 (14.07 ± 10. 8 vs 6.5 ± 5.5, p < 0.05). Oxidative stress marker (MtDNA/nDNA) is increased significantly with asthma severity and may be useful for endotyping severe asthma. La inflamación en el asma puede presentar un desequilibrio entre el estrés oxidativo y las defensas antioxidantes. El estrés oxidativo induce la propagación de la inflamación de las vías aéreas y la insensibilidad a los corticosteroides, lo que contribuye a un control deficiente del asma y a frecuentes exacerbaciones agudas graves. Este estudio evaluó la inflamación y el estrés oxidativo en sujetos asmáticos graves y estudió las posibles correlaciones entre los marcadores de estrés inflamatorio y oxidativo investigados y la gravedad del asma. Se incluyó a 53 pacientes con asma grave, 11 pacientes con asma leve a moderada y 12 sujetos sanos, a los que se les realizó un análisis de fracción exhalada de óxido nítrico (FeNO) y un recuento celular del esputo y de sangre. Se midió el contenido de ADN mitocondrial (ADNmt) y ADN nuclear (ADNn) en el condensado de aire exhalado (CAE) mediante PCR en tiempo real y se calculó la ratio ADNmt/ADNn. Detectamos ADNmt/ADNn en el CAE de los asmáticos graves. Encontramos unos niveles más altos de ADNmt/ADNn exhalados en los asmáticos graves en comparación con los leves moderados y los controles sanos (respectivamente, 10,4 ± 2,2 frente a 7,9 ± 2,5, p < 0,05 y 10,4 ± 2,2 frente a 6,51 ± 0,21, p < 0,05). El nivel de ADNmt/ADNn exhalado fue significativamente mayor en los asmáticos graves de endotipo no-T2 que en los T2 (14,07 ± 10,8 frente a 6,5 ± 5,5, p < 0,05). El marcador de estrés oxidativo (ADNmt/ADNn) aumenta significativamente con la gravedad del asma y puede ser útil para endotipar el asma grave." @default.
• W3037287210 created "2020-07-02" @default.
• W3037287210 creator A5007956054 @default.
• W3037287210 creator A5009786201 @default.
• W3037287210 creator A5016492321 @default.
• W3037287210 creator A5024276000 @default.
• W3037287210 creator A5039571641 @default.
• W3037287210 creator A5058199035 @default.
• W3037287210 creator A5075277159 @default.
• W3037287210 creator A5080602893 @default.
• W3037287210 date "2021-05-01" @default.
• W3037287210 modified "2023-10-16" @default.
• W3037287210 title "Searching for Inflammatory and Oxidative Stress Markers Capable of Clustering Severe Asthma" @default.
• W3037287210 cites W1547052876 @default.
• W3037287210 cites W1966897185 @default.
• W3037287210 cites W1967468829 @default.
• W3037287210 cites W1976091213 @default.
• W3037287210 cites W1983324034 @default.
• W3037287210 cites W1986743356 @default.
• W3037287210 cites W1989935661 @default.
• W3037287210 cites W1992263396 @default.
• W3037287210 cites W1995159146 @default.
• W3037287210 cites W1999172455 @default.
• W3037287210 cites W2016451640 @default.
• W3037287210 cites W2027553199 @default.
• W3037287210 cites W2030999077 @default.
• W3037287210 cites W2031879343 @default.
• W3037287210 cites W2036480489 @default.
• W3037287210 cites W2049472311 @default.
• W3037287210 cites W2050711948 @default.
• W3037287210 cites W2079414980 @default.
• W3037287210 cites W2085930906 @default.
• W3037287210 cites W2086332783 @default.
• W3037287210 cites W2089236773 @default.
• W3037287210 cites W2098276532 @default.
• W3037287210 cites W2112375249 @default.
• W3037287210 cites W2125078269 @default.
• W3037287210 cites W2125896682 @default.
• W3037287210 cites W2130402304 @default.
• W3037287210 cites W2134129134 @default.
• W3037287210 cites W2136455797 @default.
• W3037287210 cites W2140647407 @default.
• W3037287210 cites W2141545944 @default.
• W3037287210 cites W2150035260 @default.
• W3037287210 cites W2320858570 @default.
• W3037287210 cites W2582374071 @default.
• W3037287210 cites W2586238008 @default.
• W3037287210 cites W2586258389 @default.
• W3037287210 cites W2601675613 @default.
• W3037287210 cites W2604147277 @default.
• W3037287210 cites W2795748093 @default.
• W3037287210 cites W4211006694 @default.
• W3037287210 doi "https://doi.org/10.1016/j.arbres.2020.04.024" @default.
• W3037287210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32593535" @default.
• W3037287210 hasPublicationYear "2021" @default.
• W3037287210 type Work @default.
• W3037287210 sameAs 3037287210 @default.
• W3037287210 citedByCount "5" @default.
• W3037287210 countsByYear W30372872102021 @default.
• W3037287210 countsByYear W30372872102023 @default.
• W3037287210 crossrefType "journal-article" @default.
• W3037287210 hasAuthorship W3037287210A5007956054 @default.
• W3037287210 hasAuthorship W3037287210A5009786201 @default.
• W3037287210 hasAuthorship W3037287210A5016492321 @default.
• W3037287210 hasAuthorship W3037287210A5024276000 @default.
• W3037287210 hasAuthorship W3037287210A5039571641 @default.
• W3037287210 hasAuthorship W3037287210A5058199035 @default.
• W3037287210 hasAuthorship W3037287210A5075277159 @default.
• W3037287210 hasAuthorship W3037287210A5080602893 @default.
• W3037287210 hasConcept C126322002 @default.
• W3037287210 hasConcept C154945302 @default.
• W3037287210 hasConcept C203014093 @default.
• W3037287210 hasConcept C2776042228 @default.
• W3037287210 hasConcept C2776151105 @default.
• W3037287210 hasConcept C41008148 @default.
• W3037287210 hasConcept C71924100 @default.
• W3037287210 hasConcept C73555534 @default.
• W3037287210 hasConceptScore W3037287210C126322002 @default.
• W3037287210 hasConceptScore W3037287210C154945302 @default.
• W3037287210 hasConceptScore W3037287210C203014093 @default.
• W3037287210 hasConceptScore W3037287210C2776042228 @default.
• W3037287210 hasConceptScore W3037287210C2776151105 @default.
• W3037287210 hasConceptScore W3037287210C41008148 @default.
• W3037287210 hasConceptScore W3037287210C71924100 @default.
• W3037287210 hasConceptScore W3037287210C73555534 @default.
• W3037287210 hasIssue "5" @default.
• W3037287210 hasLocation W30372872101 @default.
• W3037287210 hasOpenAccess W3037287210 @default.
• W3037287210 hasPrimaryLocation W30372872101 @default.
• W3037287210 hasRelatedWork W2018948120 @default.
• W3037287210 hasRelatedWork W2052139239 @default.
• W3037287210 hasRelatedWork W2336746283 @default.
• W3037287210 hasRelatedWork W2374430816 @default.
• W3037287210 hasRelatedWork W2380286072 @default.
• W3037287210 hasRelatedWork W2410569622 @default.
• W3037287210 hasRelatedWork W3031481008 @default.
• W3037287210 hasRelatedWork W4235375593 @default.
• W3037287210 hasRelatedWork W4322724676 @default.

• next