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- W3037291260 endingPage "1908" @default.
- W3037291260 startingPage "1896" @default.
- W3037291260 abstract "Prenatal infection during pregnancy increases the risk for developing neuropsychiatric disorders such as schizophrenia. This is linked to an inflammatory microglial phenotype in the offspring induced by maternal immune activation (MIA). Microglia are crucial for brain development and maintenance of neuronal niches, however, whether and how their activation is involved in the regulation of neurodevelopment remains unclear. Here, we used a MIA rodent model in which polyinosinic: polycytidylic acid (poly (I:C)) was injected into pregnant mice. We found fewer parvalbumin positive (PV+) cells and impaired GABAergic transmission in the dentate gyrus (DG), accompanied by schizophrenia-like behavior in the adult offspring. Minocycline, a potent inhibitor of microglia activation, successfully prevented the above-mentioned deficits in the offspring. Furthermore, by using microglia-specific arginase 1 (Arg1) ablation as well as overexpression in DG, we identified a critical role of Arg1 in microglia activation to protect against poly (I:C) imparted neuropathology and altered behavior in offspring. Taken together, our results highlight that Arg1-mediated alternative activation of microglia are potential therapeutic targets for psychiatric disorders induced by MIA." @default.
- W3037291260 created "2020-07-02" @default.
- W3037291260 creator A5011769478 @default.
- W3037291260 creator A5014233085 @default.
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- W3037291260 creator A5047973681 @default.
- W3037291260 creator A5052981865 @default.
- W3037291260 creator A5089371991 @default.
- W3037291260 date "2020-06-29" @default.
- W3037291260 modified "2023-10-03" @default.
- W3037291260 title "Modulating microglia activation prevents maternal immune activation induced schizophrenia-relevant behavior phenotypes via arginase 1 in the dentate gyrus" @default.
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