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• W3037315152 abstract "Objective: The aim of the study was to investigate factors that may affect the dynamics of central blood pressure (cSBP) decrease during clinical trial. Design and method: We included 91 patients with moderate to severe hypertension (mean office SBP/DBP 166,1 ± 1,8/98,7 ± 1,1 mmHg; mean age 56 ± 1,2 years; 48,9 % women and 51,1% men). All patients underwent: body weight and height, office SBP, DBP (oSBP/DBP) and heart rate, elastic (PWVe) and muscle (PWVm) pulse wave velocity, central SBP, biochemical blood tests, EchoCG. Patients received either losartan 100 mg with hydrochlorothiazide 25 mg (L + HCTZ; n = 32) or lisinopril 40 mg with hydrochlorothiazide 25 mg (Liz + HCTZ; n = 32) or bisoprolol 10 mg with hydrochlorothiazide 25 mg (B + HCTZ; n = 27). If BP control was insufficient amlodipine 5 mg or 10 mg and doxazosin 2–4 mg were added. We used correlation and regression analysis. Results: oSBP/DBP decreased by 41,1 ± 2,8/17,7 ± 2,1 mmHg, while cSBP decreased by 21,3 ± 3,1 mm Hg (p < 0,01 for all). cSBP reduction significantly correlated with PWVe dynamics (r = 0,54; p = 0,001), the presence of retinopathy (r = −0,49; p = 0,03), duration of smoking (r = 0,53; p = 0,05), previous antihypertensive treatment (r = −0,49; p = 0,017), LVH (r = −0,69; p = 0,017). These relationships were significant even after correction for baseline oSBP and cSBP. Initially groups of comparison did not differ in their clinical characteristics. oSBP/DBP decreased by 4,7 ± 0,9/18,4 ± 1,1; 44,5 ± 1,9/19,0 ± 2,1 and in 42,2 ± 1,1/16,5 ± 0,8 mmHg in L + HCTZ, Liz + HCTZ and B + HCTZ groups (p < 0,01). But rates of cSBP reduction in these groups were different (-23,0 ± 2,3; -25,9 ± 2,9 and -15,4 ± 2,9 mmHg, respectively). In L + HCTZ degree of cSBP reduction correlated with BMI (r = 0,68; p = 0,04) and previous antihypertensive treatment (r = −0,84; p = 0,036), in Liz + HCTZ with LVH (r = −0,60; p = 0,012), plasma glucose (r = −0,59; p = 0,05), duration of smoking (r = −0,94; p = 0,045) and age (r = −0,53; p = 0,47), in B + HCTZ with glucose (r = −0,54, p = 0,039) and BMI (r = −0,47, p = 0,055). Conclusions: Presence of retinopathy, PWVe dynamics, duration of smoking and previous antihypertensive therapy significantly and independently correlated with cSBP reduction dynamics. These factors, as well as those that were found in study groups, should be considered when planning and performing such clinical studies." @default.
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• W3037315152 date "2015-06-01" @default.
• W3037315152 modified "2023-09-27" @default.
• W3037315152 title "PP.20.38" @default.
• W3037315152 doi "https://doi.org/10.1097/01.hjh.0000468350.57351.f9" @default.
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