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- W3037337546 abstract "Objective: The objective of the present study was to evaluate the prospective association of eGFR, calculated by using CKD-EPI, with all-cause mortality and in-hospital admissions for newly diagnosed cardiovascular endpoints in high-risk subjects from a health registry from Valencia (Spain) from 2008 to 2012.Design and method: 54,620 men and women aged 30 years or older with at least one of hypertension, diabetes mellitus and/or dyslipidemia, who attended for routine health maintenance have been selected. Patients with a history of a previous CVD event were excluded. At the time of inclusion information about CV risk factors and their active treatments as well as smoking habit and biochemistry lab values were collected from the EHR. Estimated glomerular filtration rate (eGFR) was calculated using the CKD-EPI. Participants were followed-up for the first episode of hospitalization for myocardial infarction or stroke and all cause of death were collected. Results: Hypertension was present in 76%, dyslipidemia 86%, diabetes in 35.5% and obesity in 41,8%. A total of 7884 (14.4%) patients had eGFR below 60 ml/min/1.73 m2 and among them 1807 (3.3%) 45 ml/min/1.73 m2 or lower. During a time follow-up of 3.2 years, 960 death, 1690 hospitalizations for coronary heart disease (CHD) and 1546 hospitalizations for stroke were recorded. A significant increment in the risk for total mortality was observed in subjects with eGFR 45 ml/min/1.73 m2 or below adjusted for multiple potential confounders (HR 1.83, 1.28–2.62; CI 95th). The risk for CHD or stroke hospitalizations increases across the categories of eGFR, although the HRs were no significant when adjusted for the potential confounders. A U shape in the curves was observed even that the increment of risk with the higher eGFR values have wide confidence intervals. Conclusions: eGFR is a prevalent condition in patients with the main CV risk factors. eGFR below < 45 ml/min/1.73 m2 increases mortality risk. The trend to increase risk of hyperfiltration requires further assessment." @default.
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- W3037337546 date "2015-06-01" @default.
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- W3037337546 title "PP.30.14" @default.
- W3037337546 doi "https://doi.org/10.1097/01.hjh.0000468638.97977.17" @default.
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