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- W3037372556 endingPage "115081" @default.
- W3037372556 startingPage "115081" @default.
- W3037372556 abstract "The aquatic environment takes on a key role in the dissemination of antimicrobial-resistant Enterobacteriaceae. This study assesses the occurrence of carbapenemase-producing Enterobacteriaceae (CPE) in freshwater samples from rivers, inland canals, and streams throughout Switzerland, and characterizes the isolated strains using phenotypic and NGS-based genotypic methods. CPE producing KPC-2 (n = 2), KPC-3 (n = 1), NDM-5 (n = 3), OXA-48 (n = 3), OXA-181 (n = 6), and VIM-1 (n = 2) were detected in 17/164 of the water samples. Seven Escherichia coli had sequence types (STs) that belonged to extra-intestinal pathogenic clonal lineages ST38, ST73, ST167, ST410, and ST648. The majority (16/17) of the carbapenemase genes were located on plasmids, including the widespread IncC (n = 1), IncFIIA (n = 1), and IncFIIB plasmids (n = 4), the epidemic IncL (n = 1) and IncX3 (n = 5) plasmids, a rare Col156 plasmid (n = 1), and the mosaic IncFIB, IncR, and IncQ plasmids (n = 3). Plasmids were composed of elements that were identical to those of resistance plasmids retrieved from clinical and veterinary isolates locally and worldwide. Our data show environmental dissemination of high-risk CPE clones in Switzerland. Epidemic and mosaic-like plasmids carrying clinically relevant carbapenemase genes are replicating and evolving pollutants of river ecosystems, representing a threat to public health and environmental integrity." @default.
- W3037372556 created "2020-07-02" @default.
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- W3037372556 date "2020-10-01" @default.
- W3037372556 modified "2023-10-14" @default.
- W3037372556 title "Environmental dissemination of carbapenemase-producing Enterobacteriaceae in rivers in Switzerland" @default.
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- W3037372556 doi "https://doi.org/10.1016/j.envpol.2020.115081" @default.
- W3037372556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32806462" @default.
- W3037372556 hasPublicationYear "2020" @default.
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