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- W3037398051 abstract "Abstract Cytochrome P450s from the CYP52 family participate in the assimilation of alkanes and fatty acids in fungi. In this work, the evolutionary history of a set of orthologous and paralogous CYP52 proteins from Saccharomycetales yeasts was inferred. Further, the phenotypic assimilation profiles were related with the distribution of cytochrome CYP52 members among species. The maximum likelihood phylogeny of CYP52 inferred proteins reveled a frequent ancient and modern duplication and loss events that generated orthologous and paralogous groups. Phylogeny and assimilation profiles of alkanes and fatty acids showed a family expansion in yeast isolated from hydrophobic-rich environments. Docking analysis of deduced ancient CYP52 proteins suggests that the most ancient function was the oxidation of C4-C11 alkanes, while the oxidation of >10 carbon alkanes and fatty acids is a derived character. The ancient CYP52 paralogs displayed partial specialization and promiscuous interaction with hydrophobic substrates. Additionally, functional optimization was not evident. Changes in the interaction of ancient CYP52 with different alkanes and fatty acids could be associated with modifications in spatial orientations of the amino acid residues that comprise the active site. The extended family of CYP52 proteins is likely evolving toward functional specialization, and certain redundancy for substrates is being maintained." @default.
- W3037398051 created "2020-07-02" @default.
- W3037398051 creator A5012463003 @default.
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- W3037398051 date "2020-06-24" @default.
- W3037398051 modified "2023-10-18" @default.
- W3037398051 title "Phylogeny, evolution, and potential ecological relationship of cytochrome CYP52 enzymes in Saccharomycetales yeasts" @default.
- W3037398051 cites W133296617 @default.
- W3037398051 cites W1504172537 @default.
- W3037398051 cites W1519266993 @default.
- W3037398051 cites W1563848075 @default.
- W3037398051 cites W1566143784 @default.
- W3037398051 cites W1586135266 @default.
- W3037398051 cites W1925353643 @default.
- W3037398051 cites W1963760518 @default.
- W3037398051 cites W1967598681 @default.
- W3037398051 cites W1971866201 @default.
- W3037398051 cites W1982117829 @default.
- W3037398051 cites W1983248419 @default.
- W3037398051 cites W1984353863 @default.
- W3037398051 cites W1984390786 @default.
- W3037398051 cites W1986191025 @default.
- W3037398051 cites W1990466299 @default.
- W3037398051 cites W1991170638 @default.
- W3037398051 cites W2001121208 @default.
- W3037398051 cites W2007520696 @default.
- W3037398051 cites W2012103655 @default.
- W3037398051 cites W2012507228 @default.
- W3037398051 cites W2013220267 @default.
- W3037398051 cites W2020936966 @default.
- W3037398051 cites W2028108340 @default.
- W3037398051 cites W2029667189 @default.
- W3037398051 cites W2046251649 @default.
- W3037398051 cites W2050406977 @default.
- W3037398051 cites W2052847692 @default.
- W3037398051 cites W2053490888 @default.
- W3037398051 cites W2054860928 @default.
- W3037398051 cites W2057866832 @default.
- W3037398051 cites W2060296663 @default.
- W3037398051 cites W2069455029 @default.
- W3037398051 cites W2083135851 @default.
- W3037398051 cites W2090231004 @default.
- W3037398051 cites W2105480322 @default.
- W3037398051 cites W2105668062 @default.
- W3037398051 cites W2109537731 @default.
- W3037398051 cites W2110335151 @default.
- W3037398051 cites W2112289389 @default.
- W3037398051 cites W2116713491 @default.
- W3037398051 cites W2116875566 @default.
- W3037398051 cites W2120861203 @default.
- W3037398051 cites W2125585543 @default.
- W3037398051 cites W2127579264 @default.
- W3037398051 cites W2129106405 @default.
- W3037398051 cites W2132629607 @default.
- W3037398051 cites W2137441463 @default.
- W3037398051 cites W2144367624 @default.
- W3037398051 cites W2147838733 @default.
- W3037398051 cites W2149386830 @default.
- W3037398051 cites W2149397236 @default.
- W3037398051 cites W2149531726 @default.
- W3037398051 cites W2150981663 @default.
- W3037398051 cites W2152824619 @default.
- W3037398051 cites W2157136093 @default.
- W3037398051 cites W2158920692 @default.
- W3037398051 cites W2159160717 @default.
- W3037398051 cites W2159268490 @default.
- W3037398051 cites W2169540909 @default.
- W3037398051 cites W2178650539 @default.
- W3037398051 cites W2240930686 @default.
- W3037398051 cites W2283318710 @default.
- W3037398051 cites W2312868359 @default.
- W3037398051 cites W2317044671 @default.
- W3037398051 cites W2336330109 @default.
- W3037398051 cites W2344936424 @default.
- W3037398051 cites W2548935467 @default.
- W3037398051 cites W2555870966 @default.
- W3037398051 cites W2592706484 @default.
- W3037398051 cites W2623597117 @default.
- W3037398051 cites W2741149709 @default.
- W3037398051 cites W2744896221 @default.
- W3037398051 cites W2746980362 @default.
- W3037398051 cites W2762880830 @default.
- W3037398051 cites W2765919943 @default.
- W3037398051 cites W2775650909 @default.
- W3037398051 cites W2799524357 @default.
- W3037398051 cites W2897214216 @default.
- W3037398051 cites W2906206482 @default.
- W3037398051 cites W4206799458 @default.
- W3037398051 cites W4242922021 @default.
- W3037398051 cites W4245532735 @default.
- W3037398051 cites W4254380333 @default.
- W3037398051 doi "https://doi.org/10.1038/s41598-020-67200-5" @default.
- W3037398051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7314818" @default.
- W3037398051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32581293" @default.
- W3037398051 hasPublicationYear "2020" @default.
- W3037398051 type Work @default.