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• W3037422587 abstract "ABSTRACT Physical contacts between distant loci contribute to regulate genome function. However, the molecular mechanisms responsible for settling and maintaining such interactions remain poorly understood. Here we investigate the well conserved interactions between heterochromatin loci. In budding yeast, the 32 telomeres cluster in 3-5 foci in exponentially growing cells. This clustering is functionally linked to the formation of heterochromatin in subtelomeric regions through the recruitment of the silencing complex SIR composed of Sir2/3/4. Combining microscopy and Hi-C on strains expressing different alleles of SIR3 , we show that the binding of Sir3 directly promotes long range contacts between distant regions, including the rDNA, telomeres, and internal Sir3 bound sites. Furthermore, we unveil a new property of Sir3 in promoting rDNA compaction. Finally, using a synthetic approach we demonstrate that Sir3 can bond loci belonging to different chromosomes together, when targeted to these loci, independently of its interaction with its known partners (Rap1, and Sir4), Sir2 activity or chromosome context. Altogether these data suggest that Sir3 represents an uncommon example of protein able to bridge directly distant loci." @default.
• W3037422587 created "2020-07-02" @default.
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• W3037422587 date "2020-06-29" @default.
• W3037422587 modified "2023-10-10" @default.
• W3037422587 title "The silencing factor Sir3 is a molecular bridge that sticks together distant loci" @default.
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• W3037422587 doi "https://doi.org/10.1101/2020.06.29.178368" @default.
• W3037422587 hasPublicationYear "2020" @default.
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