Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037442243> ?p ?o ?g. }
- W3037442243 endingPage "1803" @default.
- W3037442243 startingPage "1786" @default.
- W3037442243 abstract "An extension of the G1 is correlated with stem cell differentiation. The role of cell cycle regulation during the subsequent transit amplification (TA) divisions is, however, unclear. Here, we report for the first time that in the Drosophila male germline lineage, the transit amplification divisions accelerate after the second TA division. The cell cycle phases, marked by Cyclin E and Cyclin B, are progressively altered during the TA. Antagonistic functions of the bag-of-marbles and the Transforming-Growth-Factor-β signaling regulate the cell division rates after the second TA division and the extent of the Cyclin E phase during the fourth TA division. Furthermore, loss of Cyclin E during the fourth TA cycle retards the cell division and induces premature meiosis in some cases. A similar reduction of Cdk1 activity during this stage arrests the penultimate division and subsequent differentiation, whereas enhancement of the Cdk1 activity prolongs the TA by one extra round. Altogether, the results suggest that modification of the cell cycle structure and the rates of cell division after the second TA division determine the extent of amplification. Also, the regulation of the Cyclin E and CDK1 functions during the penultimate TA division determines the induction of meiosis and subsequent differentiation." @default.
- W3037442243 created "2020-07-02" @default.
- W3037442243 creator A5024285157 @default.
- W3037442243 creator A5057896068 @default.
- W3037442243 creator A5077599963 @default.
- W3037442243 creator A5088418898 @default.
- W3037442243 date "2020-06-23" @default.
- W3037442243 modified "2023-09-26" @default.
- W3037442243 title "Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in <i>Drosophila</i> testis" @default.
- W3037442243 cites W1972414581 @default.
- W3037442243 cites W1973394316 @default.
- W3037442243 cites W1991028353 @default.
- W3037442243 cites W1992588067 @default.
- W3037442243 cites W1993076246 @default.
- W3037442243 cites W1993340233 @default.
- W3037442243 cites W1994081696 @default.
- W3037442243 cites W1996098726 @default.
- W3037442243 cites W1998388174 @default.
- W3037442243 cites W1999588722 @default.
- W3037442243 cites W2008529834 @default.
- W3037442243 cites W2014957927 @default.
- W3037442243 cites W2028254835 @default.
- W3037442243 cites W2030547825 @default.
- W3037442243 cites W2033209097 @default.
- W3037442243 cites W2036817346 @default.
- W3037442243 cites W2041781614 @default.
- W3037442243 cites W2046957637 @default.
- W3037442243 cites W2047151879 @default.
- W3037442243 cites W2048109276 @default.
- W3037442243 cites W2058687436 @default.
- W3037442243 cites W2061848524 @default.
- W3037442243 cites W2067024175 @default.
- W3037442243 cites W2068437602 @default.
- W3037442243 cites W2071791128 @default.
- W3037442243 cites W2075754999 @default.
- W3037442243 cites W2078058940 @default.
- W3037442243 cites W2080972100 @default.
- W3037442243 cites W2082417649 @default.
- W3037442243 cites W2088355640 @default.
- W3037442243 cites W2094524167 @default.
- W3037442243 cites W2098770798 @default.
- W3037442243 cites W2099334597 @default.
- W3037442243 cites W2115064802 @default.
- W3037442243 cites W2116666967 @default.
- W3037442243 cites W2127699355 @default.
- W3037442243 cites W2129777634 @default.
- W3037442243 cites W2137099857 @default.
- W3037442243 cites W2138852914 @default.
- W3037442243 cites W2148407688 @default.
- W3037442243 cites W2148459495 @default.
- W3037442243 cites W2157562526 @default.
- W3037442243 cites W2159076744 @default.
- W3037442243 cites W2164528882 @default.
- W3037442243 cites W2166794059 @default.
- W3037442243 cites W2273659593 @default.
- W3037442243 cites W2297984318 @default.
- W3037442243 cites W2299231398 @default.
- W3037442243 cites W2300220838 @default.
- W3037442243 cites W2335265850 @default.
- W3037442243 cites W2373039487 @default.
- W3037442243 cites W2533168551 @default.
- W3037442243 cites W2569793307 @default.
- W3037442243 cites W2588094087 @default.
- W3037442243 cites W2588154231 @default.
- W3037442243 cites W2606201227 @default.
- W3037442243 cites W2612092003 @default.
- W3037442243 cites W2736253882 @default.
- W3037442243 cites W2740162378 @default.
- W3037442243 cites W2852804580 @default.
- W3037442243 cites W2884887817 @default.
- W3037442243 cites W2926352155 @default.
- W3037442243 doi "https://doi.org/10.1080/15384101.2020.1780381" @default.
- W3037442243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7469542" @default.
- W3037442243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32573329" @default.
- W3037442243 hasPublicationYear "2020" @default.
- W3037442243 type Work @default.
- W3037442243 sameAs 3037442243 @default.
- W3037442243 citedByCount "5" @default.
- W3037442243 countsByYear W30374422432020 @default.
- W3037442243 countsByYear W30374422432021 @default.
- W3037442243 countsByYear W30374422432022 @default.
- W3037442243 countsByYear W30374422432023 @default.
- W3037442243 crossrefType "journal-article" @default.
- W3037442243 hasAuthorship W3037442243A5024285157 @default.
- W3037442243 hasAuthorship W3037442243A5057896068 @default.
- W3037442243 hasAuthorship W3037442243A5077599963 @default.
- W3037442243 hasAuthorship W3037442243A5088418898 @default.
- W3037442243 hasBestOaLocation W30374422431 @default.
- W3037442243 hasConcept C11882975 @default.
- W3037442243 hasConcept C120089663 @default.
- W3037442243 hasConcept C120504264 @default.
- W3037442243 hasConcept C1491633281 @default.
- W3037442243 hasConcept C16438837 @default.
- W3037442243 hasConcept C2778437423 @default.
- W3037442243 hasConcept C29537977 @default.
- W3037442243 hasConcept C54355233 @default.
- W3037442243 hasConcept C85813293 @default.
- W3037442243 hasConcept C86803240 @default.