FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3037454927> ?p ?o ?g. }

• W3037454927 abstract "BACKGROUND Switching between biologic therapies is a recommended strategy for Psoriatic Arthritis (PsA) patients that show an insufficient response or adverse events. Although the choice of the subsequent biologic may be dependent on many factors, assessing the quality of the switch decision is of utmost relevance. OBJECTIVES To develop and validate two outcomes measurement tools (for patients with peripheral and axial PsA phenotypes) that address the quality of treatment decisions in PsA regarding the switch of biologic therapies in clinical practice. METHODS A Task Force and an Expert Panel were specifically assembled for this purpose. The Psoriatic Arthritis Switch Quality Assessment tool (PASQAL) development comprised a modified-Delphi method in a four-step procedure: 1) literature search and experts' opinion collection about quality indicators for PsA management; 2) Delphi design to address the development of the measurement tool; 3) three Delphi questionnaire rounds; 4) final consensus meeting. This phase resulted in the definition of two measurement tools, one to evaluate the quality of biologic switch in peripheral (pPASQAL) and another one in axial PsA (axPASQAL). For the validation of PASQAL, 12 experienced rheumatologists were asked to evaluate and classify the biologic switch of 80 clinical cases (40 with predominant peripheral and 40 with predominant axial PsA). Clinical judgement was defined to be the against which the performance of PASQAL was assessed. The results were used to assess tools' performance (sensitivity/specificity analysis) and the agreement between the tools and the gold standard (Cohen's kappa). RESULTS PASQAL consists of 6 domains (joint disease activity, dactylitis, enthesis, physical function, quality of life, and skin and nail manifestations), respective instruments and thresholds. The classification of the biologic switch was divided into three quality levels: Good, based on treat-to-target thresholds; Moderate, based on improvement from baseline; and the remaining as Insufficient. pPASQAL was found to be highly sensitive (92%) with the Good quality level and specific (97%) with the Insufficient quality level. Whilst axPASQAL showed overall higher sensitivity and specificity for all quality levels, as well as a higher level of agreement between the tool and the gold standard than pPASQAL (k=0.87 vs k=0.71). CONCLUSION PASQAL was developed and showed good criterion validity for the evaluation of the quality of switch in both peripheral and axial PsA phenotypes. These tools may be used in research as well as in clinical practice, to support rheumatologists in making more informed therapeutic decisions." @default.
• W3037454927 created "2020-07-02" @default.
• W3037454927 creator A5002875386 @default.
• W3037454927 creator A5003059891 @default.
• W3037454927 creator A5024919151 @default.
• W3037454927 creator A5042827419 @default.
• W3037454927 creator A5043668531 @default.
• W3037454927 creator A5056771856 @default.
• W3037454927 creator A5057485846 @default.
• W3037454927 creator A5078386943 @default.
• W3037454927 creator A5088107398 @default.
• W3037454927 creator A5089995923 @default.
• W3037454927 date "2020-01-01" @default.
• W3037454927 modified "2023-09-27" @default.
• W3037454927 title "Development and validation of psoriatic arthritis switch quality assessment tool (PASQAL) – an outcomes measurement tool to assess the quality of biologic switch decisions in psoriatic arthritis" @default.
• W3037454927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32578579" @default.
• W3037454927 hasPublicationYear "2020" @default.
• W3037454927 type Work @default.
• W3037454927 sameAs 3037454927 @default.
• W3037454927 citedByCount "0" @default.
• W3037454927 crossrefType "journal-article" @default.
• W3037454927 hasAuthorship W3037454927A5002875386 @default.
• W3037454927 hasAuthorship W3037454927A5003059891 @default.
• W3037454927 hasAuthorship W3037454927A5024919151 @default.
• W3037454927 hasAuthorship W3037454927A5042827419 @default.
• W3037454927 hasAuthorship W3037454927A5043668531 @default.
• W3037454927 hasAuthorship W3037454927A5056771856 @default.
• W3037454927 hasAuthorship W3037454927A5057485846 @default.
• W3037454927 hasAuthorship W3037454927A5078386943 @default.
• W3037454927 hasAuthorship W3037454927A5088107398 @default.
• W3037454927 hasAuthorship W3037454927A5089995923 @default.
• W3037454927 hasBestOaLocation W30374549272 @default.
• W3037454927 hasConcept C111472728 @default.
• W3037454927 hasConcept C126322002 @default.
• W3037454927 hasConcept C138885662 @default.
• W3037454927 hasConcept C2776260265 @default.
• W3037454927 hasConcept C2777077863 @default.
• W3037454927 hasConcept C2779530757 @default.
• W3037454927 hasConcept C71924100 @default.
• W3037454927 hasConceptScore W3037454927C111472728 @default.
• W3037454927 hasConceptScore W3037454927C126322002 @default.
• W3037454927 hasConceptScore W3037454927C138885662 @default.
• W3037454927 hasConceptScore W3037454927C2776260265 @default.
• W3037454927 hasConceptScore W3037454927C2777077863 @default.
• W3037454927 hasConceptScore W3037454927C2779530757 @default.
• W3037454927 hasConceptScore W3037454927C71924100 @default.
• W3037454927 hasLocation W30374549271 @default.
• W3037454927 hasLocation W30374549272 @default.
• W3037454927 hasLocation W30374549273 @default.
• W3037454927 hasOpenAccess W3037454927 @default.
• W3037454927 hasPrimaryLocation W30374549271 @default.
• W3037454927 hasRelatedWork W1997579941 @default.
• W3037454927 hasRelatedWork W2042020426 @default.
• W3037454927 hasRelatedWork W2139731741 @default.
• W3037454927 hasRelatedWork W2330995418 @default.
• W3037454927 hasRelatedWork W2357437675 @default.
• W3037454927 hasRelatedWork W2416284826 @default.
• W3037454927 hasRelatedWork W2478425190 @default.
• W3037454927 hasRelatedWork W2891112029 @default.
• W3037454927 hasRelatedWork W2983486367 @default.
• W3037454927 hasRelatedWork W3123999516 @default.
• W3037454927 isParatext "false" @default.
• W3037454927 isRetracted "false" @default.
• W3037454927 magId "3037454927" @default.
• W3037454927 workType "article" @default.